KOPS - The Institutional Repository of the University of Konstanz

Beyond migration : Chemokines in lymphocyte priming, differentiation, and modulating effector functions

Beyond migration : Chemokines in lymphocyte priming, differentiation, and modulating effector functions

Cite This

Files in this item

Checksum: MD5:3256b7bceb887af5623a28b32f69a967

LAUFER, Julia M., Daniel F. LEGLER, 2018. Beyond migration : Chemokines in lymphocyte priming, differentiation, and modulating effector functions. In: Journal of leukocyte biology. 104(2), pp. 301-312. ISSN 0741-5400. eISSN 1938-3673. Available under: doi: 10.1002/JLB.2MR1217-494R

@article{Laufer2018-08Beyon-42810, title={Beyond migration : Chemokines in lymphocyte priming, differentiation, and modulating effector functions}, year={2018}, doi={10.1002/JLB.2MR1217-494R}, number={2}, volume={104}, issn={0741-5400}, journal={Journal of leukocyte biology}, pages={301--312}, author={Laufer, Julia M. and Legler, Daniel F.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/42810"> <dc:contributor>Laufer, Julia M.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-07-07T13:40:16Z</dcterms:available> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42810"/> <dcterms:abstract xml:lang="eng">Chemokines and their receptors coordinate the positioning of leukocytes, and lymphocytes in particular, in space and time. Discrete lymphocyte subsets, depending on their activation and differentiation status, express various sets of chemokine receptors to be recruited to distinct tissues. Thus, the network of chemokines and their receptors ensures the correct localization of specialized lymphocyte subsets within the appropriate microenvironment enabling them to search for cognate antigens, to become activated, and to fulfill their effector functions. The chemokine system therefore is vital for the initiation as well as the regulation of immune responses to protect the body from pathogens while maintaining tolerance towards self. Besides the well investigated function of orchestrating directed cell migration, chemokines additionally act on lymphocytes in multiple ways to shape immune responses. In this review, we highlight and discuss the role of chemokines and chemokine receptors in controlling cell-to-cell contacts required for lymphocyte arrest on endothelial cells and immunological synapse formation, in lymphocyte priming and differentiation, survival, as well as in modulating effector functions.</dcterms:abstract> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/42810/1/Laufer_2-1rfj71juo8eql6.pdf"/> <dc:rights>terms-of-use</dc:rights> <dc:creator>Laufer, Julia M.</dc:creator> <dc:creator>Legler, Daniel F.</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/42810/1/Laufer_2-1rfj71juo8eql6.pdf"/> <dc:language>eng</dc:language> <dcterms:title>Beyond migration : Chemokines in lymphocyte priming, differentiation, and modulating effector functions</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-07-07T13:40:16Z</dc:date> <dc:contributor>Legler, Daniel F.</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:issued>2018-08</dcterms:issued> </rdf:Description> </rdf:RDF>

Downloads since Jul 7, 2018 (Information about access statistics)

Laufer_2-1rfj71juo8eql6.pdf 356

This item appears in the following Collection(s)

Search KOPS


Browse

My Account