Beyond migration : Chemokines in lymphocyte priming, differentiation, and modulating effector functions
Beyond migration : Chemokines in lymphocyte priming, differentiation, and modulating effector functions
Date
2018
Editors
Journal ISSN
Electronic ISSN
ISBN
Bibliographical data
Publisher
Series
URI (citable link)
DOI (citable link)
International patent number
Link to the license
EU project number
Project
Open Access publication
Collections
Title in another language
Publication type
Journal article
Publication status
Published
Published in
Journal of leukocyte biology ; 104 (2018), 2. - pp. 301-312. - ISSN 0741-5400. - eISSN 1938-3673
Abstract
Chemokines and their receptors coordinate the positioning of leukocytes, and lymphocytes in particular, in space and time. Discrete lymphocyte subsets, depending on their activation and differentiation status, express various sets of chemokine receptors to be recruited to distinct tissues. Thus, the network of chemokines and their receptors ensures the correct localization of specialized lymphocyte subsets within the appropriate microenvironment enabling them to search for cognate antigens, to become activated, and to fulfill their effector functions. The chemokine system therefore is vital for the initiation as well as the regulation of immune responses to protect the body from pathogens while maintaining tolerance towards self. Besides the well investigated function of orchestrating directed cell migration, chemokines additionally act on lymphocytes in multiple ways to shape immune responses. In this review, we highlight and discuss the role of chemokines and chemokine receptors in controlling cell-to-cell contacts required for lymphocyte arrest on endothelial cells and immunological synapse formation, in lymphocyte priming and differentiation, survival, as well as in modulating effector functions.
Summary in another language
Subject (DDC)
570 Biosciences, Biology
Keywords
adhesion, B cell, cytokine, integrin, signal transduction, T cell
Conference
Review
undefined / . - undefined, undefined. - (undefined; undefined)
Cite This
ISO 690
LAUFER, Julia M., Daniel LEGLER, 2018. Beyond migration : Chemokines in lymphocyte priming, differentiation, and modulating effector functions. In: Journal of leukocyte biology. 104(2), pp. 301-312. ISSN 0741-5400. eISSN 1938-3673. Available under: doi: 10.1002/JLB.2MR1217-494RBibTex
@article{Laufer2018-08Beyon-42810, year={2018}, doi={10.1002/JLB.2MR1217-494R}, title={Beyond migration : Chemokines in lymphocyte priming, differentiation, and modulating effector functions}, number={2}, volume={104}, issn={0741-5400}, journal={Journal of leukocyte biology}, pages={301--312}, author={Laufer, Julia M. and Legler, Daniel} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/42810"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-07-07T13:40:16Z</dcterms:available> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/42810/1/Laufer_2-1rfj71juo8eql6.pdf"/> <dc:language>eng</dc:language> <dc:contributor>Legler, Daniel</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-07-07T13:40:16Z</dc:date> <dc:rights>terms-of-use</dc:rights> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:creator>Laufer, Julia M.</dc:creator> <dcterms:issued>2018-08</dcterms:issued> <dcterms:abstract xml:lang="eng">Chemokines and their receptors coordinate the positioning of leukocytes, and lymphocytes in particular, in space and time. Discrete lymphocyte subsets, depending on their activation and differentiation status, express various sets of chemokine receptors to be recruited to distinct tissues. Thus, the network of chemokines and their receptors ensures the correct localization of specialized lymphocyte subsets within the appropriate microenvironment enabling them to search for cognate antigens, to become activated, and to fulfill their effector functions. The chemokine system therefore is vital for the initiation as well as the regulation of immune responses to protect the body from pathogens while maintaining tolerance towards self. Besides the well investigated function of orchestrating directed cell migration, chemokines additionally act on lymphocytes in multiple ways to shape immune responses. In this review, we highlight and discuss the role of chemokines and chemokine receptors in controlling cell-to-cell contacts required for lymphocyte arrest on endothelial cells and immunological synapse formation, in lymphocyte priming and differentiation, survival, as well as in modulating effector functions.</dcterms:abstract> <dc:creator>Legler, Daniel</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42810"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/42810/1/Laufer_2-1rfj71juo8eql6.pdf"/> <dc:contributor>Laufer, Julia M.</dc:contributor> <dcterms:title>Beyond migration : Chemokines in lymphocyte priming, differentiation, and modulating effector functions</dcterms:title> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> </rdf:Description> </rdf:RDF>
Internal note
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Examination date of dissertation
Method of financing
Comment on publication
Alliance license
Corresponding Authors der Uni Konstanz vorhanden
International Co-Authors
Bibliography of Konstanz
Yes
Refereed
Yes