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Ionic Dependence of Gelatin Hydrogel Architecture Explored Using Small and Very Small Angle Neutron Scattering Technique

Ionic Dependence of Gelatin Hydrogel Architecture Explored Using Small and Very Small Angle Neutron Scattering Technique

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WU, Baohu, Maria SIGLREITMEIER, Christian DEBUS, Dietmar SCHWAHN, Helmut CÖLFEN, Vitaliy PIPICH, 2018. Ionic Dependence of Gelatin Hydrogel Architecture Explored Using Small and Very Small Angle Neutron Scattering Technique. In: Macromolecular Bioscience. 18(6), 1800018. ISSN 1616-5187. eISSN 1616-5195. Available under: doi: 10.1002/mabi.201800018

@article{Wu2018-06Ionic-42668, title={Ionic Dependence of Gelatin Hydrogel Architecture Explored Using Small and Very Small Angle Neutron Scattering Technique}, year={2018}, doi={10.1002/mabi.201800018}, number={6}, volume={18}, issn={1616-5187}, journal={Macromolecular Bioscience}, author={Wu, Baohu and Siglreitmeier, Maria and Debus, Christian and Schwahn, Dietmar and Cölfen, Helmut and Pipich, Vitaliy}, note={Article Number: 1800018} }

Pipich, Vitaliy Siglreitmeier, Maria Debus, Christian Pipich, Vitaliy Ionic Dependence of Gelatin Hydrogel Architecture Explored Using Small and Very Small Angle Neutron Scattering Technique 2018-06 The hierarchical structure of gelatin hydrogels mimics a natural extracellular matrix and provides an optimized microenvironment for the growth of 3D structured tissue analogs. In the presence of metal ions, gelatin hydrogels exhibit various mechanical properties that are correlated with the molecular interactions and the hierarchical structure. The structure and structural response of gelatin hydrogels to variation of gelatin concentration, pH, or addition of metal ions are explored by small and very small angle neutron scattering over broad length scales. The measurements of the hydrogels reveal the existence of a two-level structure of colloid-like large clusters and a 3D cage-like gel network. In the presence of Fe<sup>3+</sup> ions the hydrogels show a highly dense and stiff network, while Ca<sup>2+</sup> ions have an opposite effect. The results provide important structural insight for improvement of the design of gelatin based hydrogels and are therefore suitable for various applications. 2018-06-22T12:29:32Z Wu, Baohu Cölfen, Helmut Wu, Baohu Schwahn, Dietmar Siglreitmeier, Maria 2018-06-22T12:29:32Z eng Cölfen, Helmut Debus, Christian Schwahn, Dietmar

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