Ubiquitin, E6-AP, and Their Role in p53 Inactivation

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

SCHEFFNER, Martin, 1998. Ubiquitin, E6-AP, and Their Role in p53 Inactivation. In: Pharmacology & Therapeutics. 78(3), pp. 129-139. ISSN 0163-7258. eISSN 1879-016X. Available under: doi: 10.1016/S0163-7258(98)00003-5

@article{Scheffner1998Ubiqu-42650, title={Ubiquitin, E6-AP, and Their Role in p53 Inactivation}, year={1998}, doi={10.1016/S0163-7258(98)00003-5}, number={3}, volume={78}, issn={0163-7258}, journal={Pharmacology & Therapeutics}, pages={129--139}, author={Scheffner, Martin} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/42650"> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-06-22T08:32:58Z</dc:date> <dcterms:issued>1998</dcterms:issued> <dc:contributor>Scheffner, Martin</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-06-22T08:32:58Z</dcterms:available> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:title>Ubiquitin, E6-AP, and Their Role in p53 Inactivation</dcterms:title> <dcterms:abstract xml:lang="eng">Inactivation of the tumor suppressor protein p53 plays a key role in human carcinogenesis. Activation of the growth-suppressive properties of p53 by appropriate stress signals, including genotoxic stress, is generally accompanied by intracellular accumulation of the protein. This suggests that stabilization of the otherwise short-lived protein is an intrinsic feature of p53 activation. The ubiquitin/proteasome system is believed to be a major proteolytic system involved in selective degradation of cell regulatory proteins. In this review, the potential role of the ubiquitin/proteasome system in p53 degradation and possible mechanisms involved in p53 stability regulation are discussed.</dcterms:abstract> <dc:language>eng</dc:language> <dc:creator>Scheffner, Martin</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42650"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


Browse

My Account