A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis
| Publikationstyp: | Zeitschriftenartikel |
| Publikationsstatus: | Published |
| Autor/innen: | Gisin, Jonathan; Schneider, Alexander; Nägele, Bettina; Borisova, Marina; Mayer, Christoph |
| Erscheinungsjahr: | 2013 |
| Erschienen in: | Nature Chemical Biology ; 9 (2013), 8. - S. 491-493. - ISSN 1552-4450. - eISSN 1552-4469 |
| DOI (zitierfähiger Link): | https://dx.doi.org/10.1038/nchembio.1289 |
| Zusammenfassung: |
We report a salvage pathway in Gram-negative bacteria that bypasses de novo biosynthesis of UDP N-acetylmuramic acid (UDP-MurNAc), the first committed peptidoglycan precursor, and thus provides a rationale for intrinsic fosfomycin resistance. The anomeric sugar kinase AmgK and the MurNAc α-1-phosphate uridylyl transferase MurU, defining this new cell wall sugar-recycling route in Pseudomonas putida, were characterized and engineered into Escherichia coli, channeling external MurNAc directly to peptidoglycan biosynthesis.
|
| Fachgebiet (DDC): | 570 Biowissenschaften, Biologie |
| Universitätsbibliographie: | Ja |
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GISIN, Jonathan, Alexander SCHNEIDER, Bettina NÄGELE, Marina BORISOVA, Christoph MAYER, 2013. A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. In: Nature Chemical Biology. 9(8), pp. 491-493. ISSN 1552-4450. eISSN 1552-4469. Available under: doi: 10.1038/nchembio.1289
@article{Gisin2013-08recyc-42053, title={A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis}, year={2013}, doi={10.1038/nchembio.1289}, number={8}, volume={9}, issn={1552-4450}, journal={Nature Chemical Biology}, pages={491--493}, author={Gisin, Jonathan and Schneider, Alexander and Nägele, Bettina and Borisova, Marina and Mayer, Christoph} }
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