Aufgrund von Vorbereitungen auf eine neue Version von KOPS, können kommenden Montag und Dienstag keine Publikationen eingereicht werden. (Due to preparations for a new version of KOPS, no publications can be submitted next Monday and Tuesday.)
Type of Publication: | Journal article |
Publication status: | Published |
Author: | Gisin, Jonathan; Schneider, Alexander; Nägele, Bettina; Borisova, Marina; Mayer, Christoph |
Year of publication: | 2013 |
Published in: | Nature Chemical Biology ; 9 (2013), 8. - pp. 491-493. - ISSN 1552-4450. - eISSN 1552-4469 |
DOI (citable link): | https://dx.doi.org/10.1038/nchembio.1289 |
Summary: |
We report a salvage pathway in Gram-negative bacteria that bypasses de novo biosynthesis of UDP N-acetylmuramic acid (UDP-MurNAc), the first committed peptidoglycan precursor, and thus provides a rationale for intrinsic fosfomycin resistance. The anomeric sugar kinase AmgK and the MurNAc α-1-phosphate uridylyl transferase MurU, defining this new cell wall sugar-recycling route in Pseudomonas putida, were characterized and engineered into Escherichia coli, channeling external MurNAc directly to peptidoglycan biosynthesis.
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Subject (DDC): | 570 Biosciences, Biology |
Bibliography of Konstanz: | Yes |
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GISIN, Jonathan, Alexander SCHNEIDER, Bettina NÄGELE, Marina BORISOVA, Christoph MAYER, 2013. A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. In: Nature Chemical Biology. 9(8), pp. 491-493. ISSN 1552-4450. eISSN 1552-4469. Available under: doi: 10.1038/nchembio.1289
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