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Indications that Amorphous Calcium Carbonates Occur in Pathological Mineralisation : A Urinary Stone from a Guinea Pig

Indications that Amorphous Calcium Carbonates Occur in Pathological Mineralisation : A Urinary Stone from a Guinea Pig

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Prüfsumme: MD5:5c6de86b55c733cf05f7005b1cd8f5a7

GEBAUER, Denis, Kjell JANSSON, Mikael OLIVEBERG, Niklas HEDIN, 2018. Indications that Amorphous Calcium Carbonates Occur in Pathological Mineralisation : A Urinary Stone from a Guinea Pig. In: Minerals. 8(3), 84. eISSN 2075-163X. Available under: doi: 10.3390/min8030084

@article{Gebauer2018-03Indic-41792, title={Indications that Amorphous Calcium Carbonates Occur in Pathological Mineralisation : A Urinary Stone from a Guinea Pig}, year={2018}, doi={10.3390/min8030084}, number={3}, volume={8}, journal={Minerals}, author={Gebauer, Denis and Jansson, Kjell and Oliveberg, Mikael and Hedin, Niklas}, note={Article Number: 84} }

Hedin, Niklas Hedin, Niklas Jansson, Kjell 2018-03-15T08:28:10Z Gebauer, Denis Indications that Amorphous Calcium Carbonates Occur in Pathological Mineralisation : A Urinary Stone from a Guinea Pig 2018-03-15T08:28:10Z Jansson, Kjell Oliveberg, Mikael 2018-03 Gebauer, Denis eng Calcium carbonate is an abundant biomineral that is of great importance in industrial or geological contexts. In recent years, many studies of the precipitation of CaCO<sub>3</sub> have shown that amorphous precursors and intermediates are widespread in the biomineralization processes and can also be exploited in bio-inspired materials chemistry. In this work, the thorough investigation of a urinary stone of a guinea pig suggests that amorphous calcium carbonate (ACC) can play a role in pathological mineralization. Importantly, certain analytical techniques that are often applied in the corresponding analyses are sensitive only to crystalline CaCO<sub>3</sub> and can misleadingly exclude the relevance of calcium carbonate during the formation of urinary stones. Our analyses suggest that ACC is the major constituent of the particular stone studied, which possibly precipitated on struvite nuclei. Minor amounts of urea, other stable inorganics, and minor organic inclusions are observed as well. Oliveberg, Mikael terms-of-use

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