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Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder

Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder

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BOECK, Christina, Sophia PFISTER, Alexander BÜRKLE, Valerie VANHOOREN, Claude LIBERT, Juan SALINAS-MANRIQUE, Detlef E. DIETRICH, Iris-Tatjana KOLASSA, Alexander KARABATSIAKIS, 2018. Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder. In: Journal of Affective Disorders. 234, pp. 139-147. ISSN 0165-0327. eISSN 1573-2517. Available under: doi: 10.1016/j.jad.2018.02.082

@article{Boeck2018-02-27Alter-41788, title={Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder}, year={2018}, doi={10.1016/j.jad.2018.02.082}, volume={234}, issn={0165-0327}, journal={Journal of Affective Disorders}, pages={139--147}, author={Boeck, Christina and Pfister, Sophia and Bürkle, Alexander and Vanhooren, Valerie and Libert, Claude and Salinas-Manrique, Juan and Dietrich, Detlef E. and Kolassa, Iris-Tatjana and Karabatsiakis, Alexander} }

Boeck, Christina Vanhooren, Valerie Bürkle, Alexander Libert, Claude 2018-02-27 Dietrich, Detlef E. Pfister, Sophia Karabatsiakis, Alexander Pfister, Sophia Salinas-Manrique, Juan 2018-03-15T08:13:16Z Background<br />Glycans are short chains of saccharides linked to glycoproteins that are known to be involved in a wide range of inflammatory processes. As depression has been consistently associated with chronic low-grade inflammation, we asked whether patients with Major Depressive Disorder show alterations in the N-glycosylation pattern of serum proteins that might be linked to associated changes in inflammatory processes.<br /><br />Methods<br />In a study cohort of 21 female patients with an acute depressive episode and 21 non-depressed female control subjects aged between 50 and 69 years, we analyzed the serum N-glycan profile by DNA Sequencer Adapted-Fluorophore Assisted Carbohydrate Electrophoresis (DSA-FACE) and assessed the serum levels of interleukin (IL)− 6, tumor necrosis factor (TNF)-α and C-reactive protein (CRP) by chemiluminescence immunoassays and nephelometry.<br /><br />Results<br />Compared to controls, MDD patients showed significant differences in the serum levels of several N-glycan structures. Alterations in the serum N-glycan profile were associated with depressive symptom severity and exploratory analyses revealed that they were most pronounced in MDD patients with a history of childhood sexual abuse. Furthermore, MDD patients showed higher levels of IL-6 and a trend for higher CRP levels, which were also associated with similar alterations in the serum N-glycan profile as those characteristic for MDD patients.<br /><br />Limitations<br />The relatively small sample size and the presence of potential confounders (e.g., BMI, smoking, medication).<br /><br />Conclusion<br />The results offer the first evidence that specific differences in the N-glycosylation pattern of serum proteins constitute a so far unrecognized level of biological alterations that might be involved in the immune changes associated with MDD. Libert, Claude 2018-03-15T08:13:16Z Bürkle, Alexander Dietrich, Detlef E. Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder Boeck, Christina Salinas-Manrique, Juan Kolassa, Iris-Tatjana Kolassa, Iris-Tatjana Karabatsiakis, Alexander eng Vanhooren, Valerie

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