KOPS - Das Institutionelle Repositorium der Universität Konstanz

Synthesis and EPR-spectroscopic characterization of the perchlorotriarylmethyl tricarboxylic acid radical (PTMTC) and its<sup>13</sup>C labelled analogue (<sup>13</sup>C-PTMTC)

Synthesis and EPR-spectroscopic characterization of the perchlorotriarylmethyl tricarboxylic acid radical (PTMTC) and its13C labelled analogue (13C-PTMTC)

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

ELEWA, Marwa, Nadica MALTAR-STRMEČKI, Mohamed M. SAID, Hosam A. EL SHIHAWY, Mohamed EL-SADEK, Juliane FRANK, Simon DRESCHER, Malte DRESCHER, Karsten MÄDER, Dariush HINDERBERGER, 2017. Synthesis and EPR-spectroscopic characterization of the perchlorotriarylmethyl tricarboxylic acid radical (PTMTC) and its13C labelled analogue (13C-PTMTC). In: Physical chemistry chemical physics : PCCP. 19(9), pp. 6688-6697. ISSN 1463-9076. eISSN 1463-9084. Available under: doi: 10.1039/c6cp07200c

@article{Elewa2017Synth-41744, title={Synthesis and EPR-spectroscopic characterization of the perchlorotriarylmethyl tricarboxylic acid radical (PTMTC) and its13C labelled analogue (13C-PTMTC)}, year={2017}, doi={10.1039/c6cp07200c}, number={9}, volume={19}, issn={1463-9076}, journal={Physical chemistry chemical physics : PCCP}, pages={6688--6697}, author={Elewa, Marwa and Maltar-Strmečki, Nadica and Said, Mohamed M. and El Shihawy, Hosam A. and El-Sadek, Mohamed and Frank, Juliane and Drescher, Simon and Drescher, Malte and Mäder, Karsten and Hinderberger, Dariush} }

Mäder, Karsten 2017 Frank, Juliane El Shihawy, Hosam A. Frank, Juliane Hinderberger, Dariush Elewa, Marwa Synthesis and EPR-spectroscopic characterization of the perchlorotriarylmethyl tricarboxylic acid radical (PTMTC) and its<sup>13</sup>C labelled analogue (<sup>13</sup>C-PTMTC) El-Sadek, Mohamed 2018-03-09T14:07:33Z Maltar-Strmečki, Nadica El Shihawy, Hosam A. A hydrophilic tris(tetrachlorotriaryl)methyl (tetrachloro-TAM) radical labelled 50% with<sup>13</sup>C at the central carbon atom was prepared. The mixture of isotopologue radicals was characterised by continuous wave and pulsed X-band electron paramagnetic spectroscopy (EPS). For the pharmaceutical and medical applications planned, the quantitative influence of oxygen, viscosity, temperature and pH on EPR line widths was studied in aqueous buffer, DMSO, water-methanol and water-glycerol mixtures. Under in vivo conditions, pH can be disregarded. There is a clear oxygen dependence of the width of the<sup>12</sup>C isotopologue single EPR line in aqueous solutions while changes in rotational motion (viscosity) are observable only in the doublet lines of the central carbon of the<sup>13</sup>C isotopologue. The tetrachloro-TAM proved to be very stable as a solid. Its thermal decay was determined quantitatively by thermal annealing. Towards ascorbic acid as a reducing agent and towards an oocyte cell extract it had a half-life of approx. 60 and 10 min. Thus for in vivo applications, 50%<sup>13</sup>C tetrachloro-TAMs are suitable for selective and simultaneous oxygen and macroviscosity measurements in a formulation, e.g. nanocapsules. 2018-03-09T14:07:33Z Drescher, Malte Drescher, Malte Elewa, Marwa Drescher, Simon Mäder, Karsten El-Sadek, Mohamed Said, Mohamed M. Maltar-Strmečki, Nadica eng Drescher, Simon Said, Mohamed M. Hinderberger, Dariush

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto