Psychological Stress, Inflammation, and Coronary Heart Disease

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WIRTZ, Petra H., Roland VON KÄNEL, 2017. Psychological Stress, Inflammation, and Coronary Heart Disease. In: Current Cardiology Reports. 19(11), 111. ISSN 1523-3782. eISSN 1534-3170. Available under: doi: 10.1007/s11886-017-0919-x

@article{Wirtz2017-09-20Psych-40305, title={Psychological Stress, Inflammation, and Coronary Heart Disease}, year={2017}, doi={10.1007/s11886-017-0919-x}, number={11}, volume={19}, issn={1523-3782}, journal={Current Cardiology Reports}, author={Wirtz, Petra H. and von Känel, Roland}, note={Article Number: 111} }

2017-10-11T12:37:18Z 2017-09-20 Wirtz, Petra H. Purpose of Review<br />In this review, we summarize evidence on the risk factor psychological stress in the context of coronary heart disease (CHD) in humans and explore the role of inflammation as a potential underlying mechanism.<br /><br />Recent Findings<br />While chronic stress increases the risk of incident CHD and poor cardiovascular prognosis, acute emotional stress can trigger acute CHD events in vulnerable patients. Evidence supporting a potential role for inflammation as a promising biological mechanism comes from population-based studies showing associations between chronic stress and increased inflammation. Similarly, experimental studies demonstrate acute stress-induced increases in inflammatory markers and suggest modulatory potential for pharmacological and biobehavioral interventions. So far, studies investigating patients with cardiovascular disease are few and the full sequence of events from stress to inflammation to CHD remains to be established.<br /><br />Summary<br />Psychological stress is an independent CHD risk factor associated with increased inflammation. Although promising, causality needs to be further explored. 2017-10-11T12:37:18Z von Känel, Roland eng Wirtz, Petra H. Psychological Stress, Inflammation, and Coronary Heart Disease von Känel, Roland

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