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Chronic stress suppresses anti-tumor T<sub>CD8+</sub> responses and tumor regression following cancer immunotherapy in a mouse model of melanoma

Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma

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SOMMERSHOF, Annette, Lisa SCHEUERMANN, Julia KÖRNER, Marcus GRÖTTRUP, 2017. Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma. In: Brain, Behavior, and Immunity. 65, pp. 140-149. ISSN 0889-1591. eISSN 1090-2139. Available under: doi: 10.1016/j.bbi.2017.04.021

@article{Sommershof2017-10Chron-39546, title={Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma}, year={2017}, doi={10.1016/j.bbi.2017.04.021}, volume={65}, issn={0889-1591}, journal={Brain, Behavior, and Immunity}, pages={140--149}, author={Sommershof, Annette and Scheuermann, Lisa and Körner, Julia and Gröttrup, Marcus} }

Körner, Julia eng 2017-07-11T08:09:26Z Chronic stress suppresses anti-tumor T<sub>CD8+</sub> responses and tumor regression following cancer immunotherapy in a mouse model of melanoma Animal tumor models and human cancer studies have provided convergent evidence that chronic psychological stress plays a decisive role in modulating anti-tumor T cell immunity. However, whether chronic stress also affects anti-cancer vaccine strategies that rely on the induction of functional tumor-specific T<sub>CD8+</sub> cells has not been investigated yet. In this study we provide direct evidence that chronic stress suppresses the therapeutic efficacy of a biodegradable poly(d,l-lactide-co-glycolide) microsphere (PLGA-MS) based cancer vaccine in a murine melanoma model. Exposure of mice to social disruption stress (SDR), a well-established model mimicking psychological chronic stress in humans, significantly impaired tumor protection in response to cancer vaccination under both prophylactic and therapeutic conditions. Vaccine failure in stressed mice correlated with significantly reduced generation of interferon-γ (IFN-γ)-producing T<sub>CD8+</sub> effectors and CTL-mediated killing. Phenotypic analysis of dendritic cells (DCs) revealed that both migratory and lymphoid-resident DCs failed to undergo full maturation upon antigen uptake. Notably, decreased DC maturation was associated with a significant impairment of peripheral DCs to migrate to draining LNs and to prime subsequent T<sub>CD8+</sub> responses in vivo. In conclusion, chronic stress represents an important factor mediating immunosuppression in cancer-vaccinated hosts by impairing DC functions and subsequent T<sub>CD8+</sub> priming. Potentially, the mechanistic insights gained in this study open new avenues in utilizing the full potential of anti-cancer vaccination strategies. Gröttrup, Marcus 2017-07-11T08:09:26Z Scheuermann, Lisa Sommershof, Annette 2017-10 Körner, Julia Scheuermann, Lisa Sommershof, Annette Gröttrup, Marcus

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