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Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

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JAVAHERI, Anahita, Tobias KRUSE, Kristof MOONENS, Raquel MEJÍAS-LUQUE, Ayla DEBRAEKELEER, Carmen I. ASCHE, Nicole TEGTMEYER, Behnam KALALI, Christof R. HAUCK, Markus GERHARD, 2016. Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. In: Nature Microbiology. 2, 16189. eISSN 2058-5276. Available under: doi: 10.1038/nmicrobiol.2016.189

@article{Javaheri2016Helic-39087, title={Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs}, year={2016}, doi={10.1038/nmicrobiol.2016.189}, volume={2}, journal={Nature Microbiology}, author={Javaheri, Anahita and Kruse, Tobias and Moonens, Kristof and Mejías-Luque, Raquel and Debraekeleer, Ayla and Asche, Carmen I. and Tegtmeyer, Nicole and Kalali, Behnam and Hauck, Christof R. and Gerhard, Markus}, note={Article Number: 16189} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/39087"> <dc:contributor>Mejías-Luque, Raquel</dc:contributor> <dc:contributor>Kalali, Behnam</dc:contributor> <dc:contributor>Debraekeleer, Ayla</dc:contributor> <dc:contributor>Tegtmeyer, Nicole</dc:contributor> <dc:creator>Asche, Carmen I.</dc:creator> <dc:creator>Debraekeleer, Ayla</dc:creator> <dc:contributor>Kruse, Tobias</dc:contributor> <dc:creator>Mejías-Luque, Raquel</dc:creator> <dc:contributor>Asche, Carmen I.</dc:contributor> <dc:contributor>Javaheri, Anahita</dc:contributor> <dcterms:title>Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-06-01T06:15:25Z</dc:date> <dc:creator>Tegtmeyer, Nicole</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Kruse, Tobias</dc:creator> <dc:contributor>Gerhard, Markus</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/39087"/> <dcterms:abstract xml:lang="eng">Helicobacter pylori specifically colonizes the human gastric epithelium and is the major causative agent for ulcer disease and gastric cancer development. Here, we identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of H. pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. HopQ-CEACAM binding is glycan-independent and targeted to the N-domain. H. pylori binding induces CEACAM1-mediated signalling, and the HopQ-CEACAM1 interaction enables translocation of the virulence factor CagA into host cells and enhances the release of pro-inflammatory mediators such as interleukin-8. Based on the crystal structure of HopQ, we found that a β-hairpin insertion (HopQ-ID) in HopQ's extracellular 3+4 helix bundle domain is important for CEACAM binding. A peptide derived from this domain competitively inhibits HopQ-mediated activation of the Cag virulence pathway, as genetic or antibody-mediated abrogation of the HopQ function shows. Together, our data suggest the HopQ-CEACAM1 interaction to be a potentially promising novel therapeutic target to combat H. pylori-associated diseases.</dcterms:abstract> <dc:language>eng</dc:language> <dc:contributor>Moonens, Kristof</dc:contributor> <dc:creator>Hauck, Christof R.</dc:creator> <dc:contributor>Hauck, Christof R.</dc:contributor> <dc:creator>Javaheri, Anahita</dc:creator> <dc:creator>Moonens, Kristof</dc:creator> <dc:creator>Kalali, Behnam</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-06-01T06:15:25Z</dcterms:available> <dcterms:issued>2016</dcterms:issued> <dc:creator>Gerhard, Markus</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> </rdf:Description> </rdf:RDF>

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