Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding
| Type of Publication: | Journal article |
| Publication status: | Published |
| Author: | Robotta, Marta; Cattani, Julia; Martins, Juliana Cristina; Subramaniam, Vinod; Drescher, Malte |
| Year of publication: | 2017 |
| Published in: | Journal of the American Chemical Society : JACS ; 139 (2017), 12. - pp. 4254-4257. - ISSN 0002-7863. - eISSN 1520-5126 |
| Pubmed ID: | 28298083 |
| DOI (citable link): | https://dx.doi.org/10.1021/jacs.6b05335 |
| Summary: |
The intrinsically disordered human protein alpha-Synuclein (αS) has a prominent role in Parkinson's disease (PD) pathology. Several familial variants of αS are correlated with inherited PD. Disease mutations have been shown to have an impact on lipid membrane binding. Here, using electron paramagnetic resonance spectroscopy in combination with site-directed spin labeling, we show that familial PD-associated variants are structurally defective in membrane binding and alter the local binding properties of the protein.
|
| Subject (DDC): | 540 Chemistry |
| Bibliography of Konstanz: | Yes |
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ROBOTTA, Marta, Julia CATTANI, Juliana Cristina MARTINS, Vinod SUBRAMANIAM, Malte DRESCHER, 2017. Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding. In: Journal of the American Chemical Society : JACS. 139(12), pp. 4254-4257. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/jacs.6b05335
@article{Robotta2017-03-29Alpha-39012, title={Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding}, year={2017}, doi={10.1021/jacs.6b05335}, number={12}, volume={139}, issn={0002-7863}, journal={Journal of the American Chemical Society : JACS}, pages={4254--4257}, author={Robotta, Marta and Cattani, Julia and Martins, Juliana Cristina and Subramaniam, Vinod and Drescher, Malte} }
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