Ligand-dependent ribozymes

Cite This

Files in this item

Checksum: MD5:6d72f32553d40bd0929955243f375183

FELLETTI, Michele, Jörg S. HARTIG, 2017. Ligand-dependent ribozymes. In: Wiley Interdisciplinary Reviews (WIREs) : RNA. 8(2), e1395. ISSN 1757-7004. eISSN 1757-7012. Available under: doi: 10.1002/wrna.1395

@article{Felletti2017-03Ligan-38789, title={Ligand-dependent ribozymes}, year={2017}, doi={10.1002/wrna.1395}, number={2}, volume={8}, issn={1757-7004}, journal={Wiley Interdisciplinary Reviews (WIREs) : RNA}, author={Felletti, Michele and Hartig, Jörg S.}, note={Article Number: e1395} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:abstract xml:lang="eng">The discovery of catalytic RNA (ribozymes) more than 30 years ago significantly widened the horizon of RNA-based functions in natural systems. Similarly to the activity of protein enzymes that are often modulated by the presence of an interaction partner, some examples of naturally occurring ribozymes are influenced by ligands that can either act as cofactors or allosteric modulators. Recent discoveries of new and widespread ribozyme motifs in many different genetic contexts point toward the existence of further ligand-dependent RNA catalysts. In addition to the presence of ligand-dependent ribozymes in nature, researchers have engineered ligand dependency into natural and artificial ribozymes. Because RNA functions can often be assembled in a truly modular way, many different systems have been obtained utilizing different ligand-sensing domains and ribozyme activities in diverse applications. We summarize the occurrence of ligand-dependent ribozymes in nature and the many examples realized by researchers that engineered ligand-dependent catalytic RNA motifs. We will also highlight methods for obtaining ligand dependency as well as discuss the many interesting applications of ligand-controlled catalytic RNAs.</dcterms:abstract> <dc:creator>Hartig, Jörg S.</dc:creator> <dcterms:title>Ligand-dependent ribozymes</dcterms:title> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:rights>terms-of-use</dc:rights> <dcterms:hasPart rdf:resource=""/> <dcterms:issued>2017-03</dcterms:issued> <dcterms:isPartOf rdf:resource=""/> <dcterms:available rdf:datatype="">2017-05-08T15:05:22Z</dcterms:available> <dspace:hasBitstream rdf:resource=""/> <bibo:uri rdf:resource=""/> <dc:contributor>Felletti, Michele</dc:contributor> <dc:creator>Felletti, Michele</dc:creator> <dc:date rdf:datatype="">2017-05-08T15:05:22Z</dc:date> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:rights rdf:resource=""/> <dc:contributor>Hartig, Jörg S.</dc:contributor> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

Downloads since May 8, 2017 (Information about access statistics)

Felletti_0-405944.pdf 620

This item appears in the following Collection(s)

Search KOPS


My Account