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Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD<sup>+</sup> analogues

Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues

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Prüfsumme: MD5:05c59e28b9430e2169b1b10ecdd0d5aa

WALLRODT, Sarah, Edward L. SIMPSON, Andreas MARX, 2017. Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues. In: Beilstein Journal of Organic Chemistry. 13, pp. 495-501. eISSN 1860-5397

@article{Wallrodt2017-03-10Inves-38625, title={Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues}, year={2017}, doi={10.3762/bjoc.13.49}, volume={13}, journal={Beilstein Journal of Organic Chemistry}, pages={495--501}, author={Wallrodt, Sarah and Simpson, Edward L. and Marx, Andreas} }

Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD<sup>+</sup> analogues eng 2017-04-27T06:03:57Z Wallrodt, Sarah Simpson, Edward L. Marx, Andreas 2017-04-27T06:03:57Z Simpson, Edward L. Wallrodt, Sarah ADP-ribosyl transferases with diphtheria toxin homology (ARTDs) catalyse the covalent addition of ADP-ribose onto different acceptors forming mono- or poly(ADP-ribos)ylated proteins. Out of the 18 members identified, only four are known to synthesise the complex poly(ADP-ribose) biopolymer. The investigation of this posttranslational modification is important due to its involvement in cancer and other diseases. Lately, metabolic labelling approaches comprising different reporter-modified NAD<sup>+</sup> building blocks have stimulated and enriched proteomic studies and imaging applications of ADP-ribosylation processes. Herein, we compare the substrate scope and applicability of different NAD<sup>+</sup> analogues for the investigation of the polymer-synthesising enzymes ARTD1, ARTD2, ARTD5 and ARTD6. By varying the site and size of the NAD<sup>+</sup> modification, suitable probes were identified for each enzyme. This report provides guidelines for choosing analogues for studying poly(ADP-ribose)-synthesising enzymes. Marx, Andreas 2017-03-10

Dateiabrufe seit 27.04.2017 (Informationen über die Zugriffsstatistik)

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