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Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers

Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers

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Prüfsumme: MD5:09cd7d711bde6d71da0d4aae92d9f070

BOOIJ, Linda, Krzysztof WELFELD, Marco LEYTON, Alain DAGHER, Isabelle BOILEAU, Igor SIBON, Glen B. BAKER, Mirko DIKSIC, Jens PRÜSSNER, Chawki BENKELFAT, 2016. Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers. In: Translational Psychiatry. 6(2), e740. eISSN 2158-3188. Available under: doi: 10.1038/tp.2016.6

@article{Booij2016Dopam-38207, title={Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers}, year={2016}, doi={10.1038/tp.2016.6}, number={2}, volume={6}, journal={Translational Psychiatry}, author={Booij, Linda and Welfeld, Krzysztof and Leyton, Marco and Dagher, Alain and Boileau, Isabelle and Sibon, Igor and Baker, Glen B. and Diksic, Mirko and Prüßner, Jens and Benkelfat, Chawki}, note={Article Number: e740} }

Sibon, Igor Boileau, Isabelle eng Welfeld, Krzysztof Baker, Glen B. 2016 Diksic, Mirko Benkelfat, Chawki Booij, Linda Prüßner, Jens 2017-03-30T07:44:33Z Baker, Glen B. Sibon, Igor Welfeld, Krzysztof Dagher, Alain 2017-03-30T07:44:33Z Diksic, Mirko Leyton, Marco Boileau, Isabelle Leyton, Marco Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers Dysregulation of the stress response system is a potential etiological factor in the development of and relapse to multiple neuropsychiatric disorders. Previously we reported that repeated intermittent d-amphetamine administration can lead to progressively greater dopamine release, thereby providing evidence of drug-induced neurochemical sensitization. Here, we test the hypothesis that repeated exposure to d-amphetamine increases dopaminergic responses to stress; that is, produces cross-sensitization. Using positron emission tomography, we measured in 17 healthy male volunteers (mean ± s.d. = 22.1 ± 3.4 years) [(11)C]raclopride binding responses to a validated psychosocial stress task before and 2 weeks after a regimen of repeated d-amphetamine (3 × 0.3 mg kg(-1), by mouth; n = 8) or placebo (3 × lactose, by mouth; n = 9). Mood and physiological measurements were recorded throughout each session. Before the d-amphetamine regimen, exposure to the stress task increased behavioral and physiological indices of stress (anxiety, heart rate, cortisol, all P ⩽ 0.05). Following the d-amphetamine regimen, the stress-induced cortisol responses were augmented (P < 0.04), and voxel-based analyses showed larger stress-induced decreases in [(11)C]raclopride non-displaceable binding potential across the striatum. In the placebo group, re-exposure to stress led to smaller clusters of decreased [(11)C]raclopride binding, primarily in the sensorimotor striatum (P < 0.05). Together, this study provides evidence for drug × stress cross-sensitization; moreover, random exposure to stimulants and/or stress cumulatively, while enhancing dopamine release in striatal areas, may contribute to a lowered set point for psychopathologies in which altered dopamine neurotransmission is invoked. Benkelfat, Chawki Dagher, Alain Prüßner, Jens Booij, Linda

Dateiabrufe seit 30.03.2017 (Informationen über die Zugriffsstatistik)

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