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Is the association of alcohol use disorders with major depressive disorder a consequence of undiagnosed bipolar-II disorder?

Is the association of alcohol use disorders with major depressive disorder a consequence of undiagnosed bipolar-II disorder?

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ANGST, Jules, Alex GAMMA, Jérôme ENDRASS, Wulf RÖSSLER, Valdeta AJDACIC-GROSS, Dominique EICH, Richard HERRELL, Kathleen Ries MERIKANGAS, 2006. Is the association of alcohol use disorders with major depressive disorder a consequence of undiagnosed bipolar-II disorder?. In: European Archives of Psychiatry and Clinical Neuroscience. 256(7), pp. 452-457. ISSN 0940-1334. eISSN 1433-8491

@article{Angst2006-10assoc-38023, title={Is the association of alcohol use disorders with major depressive disorder a consequence of undiagnosed bipolar-II disorder?}, year={2006}, doi={10.1007/s00406-006-0673-3}, number={7}, volume={256}, issn={0940-1334}, journal={European Archives of Psychiatry and Clinical Neuroscience}, pages={452--457}, author={Angst, Jules and Gamma, Alex and Endrass, Jérôme and Rössler, Wulf and Ajdacic-Gross, Valdeta and Eich, Dominique and Herrell, Richard and Merikangas, Kathleen Ries} }

Ajdacic-Gross, Valdeta Rössler, Wulf 2017-03-17T07:06:07Z Ajdacic-Gross, Valdeta Herrell, Richard Background<br /><br />There is emerging evidence that there is a spectrum of expression of bipolar disorder. This paper uses the well-established patterns of comorbidity of mood and alcohol use disorder to test the hypothesis that application of an expanded concept of bipolar-II (BP-II) disorder might largely explain the association of alcohol use disorders (AUD) with major depressive disorder (MDD).<br /><br />Method<br /><br />Data from the Zurich study, a community cohort assessed over 6 waves from ages 20/21 to 40/41, were used to investigate the comorbidity between mood disorders and AUD. Systematic diagnostic criteria were used for alcohol abuse, alcohol dependence, MDD, and BP-II. In addition to DSM criteria, two increasingly broad definitions of BP-II were employed.<br /><br />Results<br /><br />There was substantially greater comorbidity for the BP-II compared to major depression and for alcohol dependence compared to alcohol abuse. The broadest concept of BP-II explained two thirds of all cases of comorbidity of AUD with major depressive episodes (MDE). In fact, the broader the definition of BP-II applied, the smaller was the association of AUD with MDD, up to non-significance. In the majority of cases, the onset of bipolar manifestations preceded that of drinking problems by at least 5 years.<br /><br />Conclusions<br /><br />The findings that the comorbidity of mood disorders with AUD was primarily attributable to BP-II rather than MDD and that bipolar symptoms usually preceded alcohol problems may encourage new approaches to prevention and treatment of AUD. 2006-10 Eich, Dominique Merikangas, Kathleen Ries Herrell, Richard eng Is the association of alcohol use disorders with major depressive disorder a consequence of undiagnosed bipolar-II disorder? Gamma, Alex Endrass, Jérôme Eich, Dominique Endrass, Jérôme Rössler, Wulf Angst, Jules Gamma, Alex Angst, Jules Merikangas, Kathleen Ries 2017-03-17T07:06:07Z

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