Regulation of Cell Division

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HEIM, Andreas, Beata RYMARCZYK, Saurav MALHOTRA, Thomas U. MAYER, 2017. Regulation of Cell Division. In: PELEGRI, Francisco, ed., Michael DANILCHIK, ed., Ann SUTHERLAND, ed.. Vertebrate Development : Maternal to Zygotic Control. Cham:Springer International Publishing, pp. 83-116. ISBN 978-3-319-46093-2

@incollection{Heim2017Regul-37730, title={Regulation of Cell Division}, year={2017}, doi={10.1007/978-3-319-46095-6_3}, number={953}, isbn={978-3-319-46093-2}, address={Cham}, publisher={Springer International Publishing}, series={Advances in Experimental Medicine and Biology}, booktitle={Vertebrate Development : Maternal to Zygotic Control}, pages={83--116}, editor={Pelegri, Francisco and Danilchik, Michael and Sutherland, Ann}, author={Heim, Andreas and Rymarczyk, Beata and Malhotra, Saurav and Mayer, Thomas U.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/37730"> <dc:contributor>Mayer, Thomas U.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-27T13:51:48Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-27T13:51:48Z</dc:date> <dc:language>eng</dc:language> <dcterms:abstract xml:lang="eng">The challenging task of mitotic cell divisions is to generate two genetically identical daughter cells from a single precursor cell. To accomplish this task, a complex regulatory network evolved, which ensures that all events critical for the duplication of cellular contents and their subsequent segregation occur in the correct order, at specific intervals and with the highest possible fidelity. Transitions between cell cycle stages are triggered by changes in the phosphorylation state and levels of components of the cell cycle machinery. Entry into S-phase and M-phase are mediated by cyclin-dependent kinases (Cdks), serine-threonine kinases that require a regulatory cyclin subunit for their activity. Resetting the system to the interphase state is mediated by protein phosphatases (PPs) that counteract Cdks by dephosphorylating their substrates. To avoid futile cycles of phosphorylation and dephosphorylation, Cdks and PPs must be regulated in a manner such that their activities are mutually exclusive.</dcterms:abstract> <dc:creator>Malhotra, Saurav</dc:creator> <dc:contributor>Malhotra, Saurav</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/37730"/> <dc:creator>Heim, Andreas</dc:creator> <dc:creator>Rymarczyk, Beata</dc:creator> <dcterms:issued>2017</dcterms:issued> <dc:creator>Mayer, Thomas U.</dc:creator> <dc:contributor>Heim, Andreas</dc:contributor> <dc:contributor>Rymarczyk, Beata</dc:contributor> <dcterms:title>Regulation of Cell Division</dcterms:title> </rdf:Description> </rdf:RDF>

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