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Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2

Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2

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KAESLER, Susanne, Yuliya SKABYTSKA, Ko-Ming CHEN, Wolfgang E. KEMPF, Thomas VOLZ, Martin KÖBERLE, Florian WÖLBING, Ulrike HEIN, Thomas HARTUNG, Tilo BIEDERMANN, 2016. Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2. In: Journal of Allergy and Clinical Immunology. 138(3), pp. 780-790.e6. ISSN 0091-6749. eISSN 1097-6825

@article{Kaesler2016Staph-37561, title={Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2}, year={2016}, doi={10.1016/j.jaci.2015.11.043}, number={3}, volume={138}, issn={0091-6749}, journal={Journal of Allergy and Clinical Immunology}, pages={780--790.e6}, author={Kaesler, Susanne and Skabytska, Yuliya and Chen, Ko-Ming and Kempf, Wolfgang E. and Volz, Thomas and Köberle, Martin and Wölbing, Florian and Hein, Ulrike and Hartung, Thomas and Biedermann, Tilo} }

Volz, Thomas Biedermann, Tilo Köberle, Martin Kempf, Wolfgang E. Chen, Ko-Ming Kaesler, Susanne Chen, Ko-Ming Background<br /><br />The interplay between microbes and surface organs, such as the skin, shapes a complex immune system with several checks and balances. The first-line defense is mediated by innate immune pathways leading to inflammation. In the second phase specific T cells invade the infected organ, amplifying inflammation and defense. Consecutively, termination of inflammation is crucial to avoid chronic inflammation triggered by microbes, such as in patients with atopic dermatitis.<br /><br />Objective<br /><br />We aimed to elucidate how the Staphylococcus aureus–derived cell-wall component lipoteichoic acid (LTA) governs the second phase of immune responses when high concentrations of LTA access T cells directly through disrupted skin.<br /><br />Methods<br /><br />We analyzed the direct exposure of T cells to LTA in vitro. For in vivo analyses, we used fluorescein isothiocyanate contact hypersensitivity and ovalbumin-induced dermatitis as models for T<sub>H</sub>2-mediated cutaneous inflammation.<br /><br />Results<br /><br />We observed that LTA potently suppressed T-lymphocyte activation in a Toll-like receptor 2–independent manner. LTA-exposed T cells did not proliferate and did not produce cytokines. Importantly, these T cells remained completely viable and were responsive to consecutive activation signals on subsequent removal of LTA. Thus LTA exposure resulted in temporary functional T-cell paralysis. In vivo experiments revealed that T-cell cytokine production and cutaneous recall responses were significantly suppressed by LTA.<br /><br />Conclusion<br /><br />We identified a new mechanism through which bacterial compounds directly but temporarily modulate adaptive immune responses. Hein, Ulrike Kaesler, Susanne 2016 Wölbing, Florian Köberle, Martin Hartung, Thomas eng Hein, Ulrike 2017-02-17T10:38:13Z Skabytska, Yuliya Wölbing, Florian Staphylococcus aureus–derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2 2017-02-17T10:38:13Z Skabytska, Yuliya Hartung, Thomas Volz, Thomas Kempf, Wolfgang E. Biedermann, Tilo

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