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Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

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Prüfsumme: MD5:e4518eec9bf9f3643c55c31e074479e0

SCHUMANN, Kathrin, Tim LÄMMERMANN, Markus BRUCKNER, Daniel F. LEGLER, Julien POLLEUX, Joachim P. SPATZ, Gerold SCHULER, Reinhold FÖRSTER, Manfred B. LUTZ, Michael SIXT, 2010. Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells. In: Immunity. 32(5), pp. 703-713. ISSN 1074-7613. eISSN 1097-4180

@article{Schumann2010Immob-36602, title={Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells}, year={2010}, doi={10.1016/j.immuni.2010.04.017}, number={5}, volume={32}, issn={1074-7613}, journal={Immunity}, pages={703--713}, author={Schumann, Kathrin and Lämmermann, Tim and Bruckner, Markus and Legler, Daniel F. and Polleux, Julien and Spatz, Joachim P. and Schuler, Gerold and Förster, Reinhold and Lutz, Manfred B. and Sixt, Michael} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/36602"> <dc:contributor>Polleux, Julien</dc:contributor> <dc:creator>Förster, Reinhold</dc:creator> <dc:contributor>Legler, Daniel F.</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-12T08:05:53Z</dc:date> <dc:contributor>Bruckner, Markus</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/36602"/> <dcterms:title>Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells</dcterms:title> <dc:creator>Lutz, Manfred B.</dc:creator> <dc:contributor>Schumann, Kathrin</dc:contributor> <dc:contributor>Spatz, Joachim P.</dc:contributor> <dc:contributor>Lämmermann, Tim</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-12T08:05:53Z</dcterms:available> <dcterms:issued>2010</dcterms:issued> <dc:creator>Spatz, Joachim P.</dc:creator> <dc:contributor>Sixt, Michael</dc:contributor> <dc:creator>Legler, Daniel F.</dc:creator> <dc:creator>Polleux, Julien</dc:creator> <dc:creator>Schumann, Kathrin</dc:creator> <dc:creator>Lämmermann, Tim</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:language>eng</dc:language> <dc:creator>Sixt, Michael</dc:creator> <dcterms:abstract xml:lang="eng">Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic cell (DC) migration, we showed that these distinct cellular responses depended on the mode of chemokine presentation within tissues. The surface-immobilized form of the chemokine CCL21, the heparan sulfate-anchoring ligand of the CC-chemokine receptor 7 (CCR7), caused random movement of DCs that was confined to the chemokine-presenting surface because it triggered integrin-mediated adhesion. Upon direct contact with CCL21, DCs truncated the anchoring residues of CCL21, thereby releasing it from the solid phase. Soluble CCL21 functionally resembles the second CCR7 ligand, CCL19, which lacks anchoring residues and forms soluble gradients. Both soluble CCR7 ligands triggered chemotactic movement, but not surface adhesion. Adhesive random migration and directional steering cooperate to produce dynamic but spatially restricted locomotion patterns closely resembling the cellular dynamics observed in secondary lymphoid organs.</dcterms:abstract> <dc:contributor>Förster, Reinhold</dc:contributor> <dc:contributor>Lutz, Manfred B.</dc:contributor> <dc:contributor>Schuler, Gerold</dc:contributor> <dc:creator>Schuler, Gerold</dc:creator> <dc:creator>Bruckner, Markus</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 12.01.2017 (Informationen über die Zugriffsstatistik)

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