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CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

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ZHOU, Tiankun, Jennifer R. FLEMING, Barbara FRANKE, Julius BOGOMOLOVAS, Igor BARSUKOV, Daniel J. RIGDEN, Siegfried LABEIT, Olga MAYANS, 2016. CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex. In: FEBS Letters. 590(18), pp. 3098-3110. ISSN 0014-5793. eISSN 1873-3468

@article{Zhou2016-09inter-36547, title={CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex}, year={2016}, doi={10.1002/1873-3468.12362}, number={18}, volume={590}, issn={0014-5793}, journal={FEBS Letters}, pages={3098--3110}, author={Zhou, Tiankun and Fleming, Jennifer R. and Franke, Barbara and Bogomolovas, Julius and Barsukov, Igor and Rigden, Daniel J. and Labeit, Siegfried and Mayans, Olga} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/36547"> <dc:creator>Franke, Barbara</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-10T13:22:33Z</dc:date> <dc:contributor>Zhou, Tiankun</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-10T13:22:33Z</dcterms:available> <dc:contributor>Fleming, Jennifer R.</dc:contributor> <dc:creator>Fleming, Jennifer R.</dc:creator> <dc:contributor>Rigden, Daniel J.</dc:contributor> <dcterms:issued>2016-09</dcterms:issued> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:language>eng</dc:language> <dcterms:abstract xml:lang="eng">The cardiac ankyrin repeat protein (CARP) is up-regulated in the myocardium during cardiovascular disease and in response to mechanical or toxic stress. Stress-induced CARP interacts with the N2A spring region of the titin filament to modulate muscle compliance. We characterize the interaction between CARP and titin-N2A and show that the binding site in titin spans the dual domain UN2A-Ig81. We find that the unique sequence UN2A is not structurally disordered, but that it has a stable, elongated α-helical fold that possibly acts as a constant force spring. Our findings portray CARP/titin-N2A as a structured node and help to rationalize the molecular basis of CARP mechanosensing in the sarcomeric I-band.</dcterms:abstract> <dc:creator>Labeit, Siegfried</dc:creator> <dcterms:title>CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex</dcterms:title> <dc:contributor>Mayans, Olga</dc:contributor> <dc:contributor>Barsukov, Igor</dc:contributor> <dc:contributor>Bogomolovas, Julius</dc:contributor> <dc:creator>Mayans, Olga</dc:creator> <dc:creator>Rigden, Daniel J.</dc:creator> <dc:contributor>Franke, Barbara</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/36547"/> <dc:creator>Zhou, Tiankun</dc:creator> <dc:creator>Barsukov, Igor</dc:creator> <dc:contributor>Labeit, Siegfried</dc:contributor> <dc:creator>Bogomolovas, Julius</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 10.01.2017 (Informationen über die Zugriffsstatistik)

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