Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering
| Type of Publication: | Journal article |
| Publication status: | Published |
| URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-0-372725 |
| Author: | Hardy, John G.; Torres-Rendon, Jose Guillermo; Leal-Egaña, Aldo; Walther, Andreas; Schlaad, Helmut; Cölfen, Helmut; Scheibel, Thomas R. |
| Year of publication: | 2016 |
| Published in: | Materials ; 9 (2016), 7. - 560. - eISSN 1996-1944 |
| DOI (citable link): | https://dx.doi.org/10.3390/ma9070560 |
| Summary: |
Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue Engineering.
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| Subject (DDC): | 540 Chemistry |
| Keywords: | spider silk; recombinant protein; biodegradable polymers; biomaterials; biomineralization; bone tissue engineering |
| Link to License: | In Copyright |
| Bibliography of Konstanz: | Yes |
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HARDY, John G., Jose Guillermo TORRES-RENDON, Aldo LEAL-EGAÑA, Andreas WALTHER, Helmut SCHLAAD, Helmut CÖLFEN, Thomas R. SCHEIBEL, 2016. Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering. In: Materials. 9(7), 560. eISSN 1996-1944. Available under: doi: 10.3390/ma9070560
@article{Hardy2016-07-11Biomi-35921, title={Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering}, year={2016}, doi={10.3390/ma9070560}, number={7}, volume={9}, journal={Materials}, author={Hardy, John G. and Torres-Rendon, Jose Guillermo and Leal-Egaña, Aldo and Walther, Andreas and Schlaad, Helmut and Cölfen, Helmut and Scheibel, Thomas R.}, note={Article Number: 560} }
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