Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering
| Publikationstyp: | Zeitschriftenartikel |
| Publikationsstatus: | Published |
| URI (zitierfähiger Link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-0-372725 |
| Autor/innen: | Hardy, John G.; Torres-Rendon, Jose Guillermo; Leal-Egaña, Aldo; Walther, Andreas; Schlaad, Helmut; Cölfen, Helmut; Scheibel, Thomas R. |
| Erscheinungsjahr: | 2016 |
| Erschienen in: | Materials ; 9 (2016), 7. - 560. - eISSN 1996-1944 |
| DOI (zitierfähiger Link): | https://dx.doi.org/10.3390/ma9070560 |
| Zusammenfassung: |
Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue Engineering.
|
| Fachgebiet (DDC): | 540 Chemie |
| Schlagwörter: | spider silk; recombinant protein; biodegradable polymers; biomaterials; biomineralization; bone tissue engineering |
| Link zur Lizenz: | Nutzungsbedingungen |
| Universitätsbibliographie: | Ja |
Zitieren
Dateien zu dieser Ressource
![[PDF]](/themes/Kops/images/mimes/pdf.png "PDF file"){kind=small}
HARDY, John G., Jose Guillermo TORRES-RENDON, Aldo LEAL-EGAÑA, Andreas WALTHER, Helmut SCHLAAD, Helmut CÖLFEN, Thomas R. SCHEIBEL, 2016. Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering. In: Materials. 9(7), 560. eISSN 1996-1944. Available under: doi: 10.3390/ma9070560
@article{Hardy2016-07-11Biomi-35921, title={Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering}, year={2016}, doi={10.3390/ma9070560}, number={7}, volume={9}, journal={Materials}, author={Hardy, John G. and Torres-Rendon, Jose Guillermo and Leal-Egaña, Aldo and Walther, Andreas and Schlaad, Helmut and Cölfen, Helmut and Scheibel, Thomas R.}, note={Article Number: 560} }
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/35921"> <dc:rights>terms-of-use</dc:rights> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Walther, Andreas</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-11-15T14:05:16Z</dc:date> <dc:contributor>Schlaad, Helmut</dc:contributor> <dc:creator>Leal-Egaña, Aldo</dc:creator> <dc:contributor>Scheibel, Thomas R.</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Torres-Rendon, Jose Guillermo</dc:creator> <dc:creator>Scheibel, Thomas R.</dc:creator> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <dcterms:abstract xml:lang="eng">Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue Engineering.</dcterms:abstract> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dcterms:title>Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering</dcterms:title> <dc:creator>Cölfen, Helmut</dc:creator> <dcterms:issued>2016-07-11</dcterms:issued> <dc:contributor>Hardy, John G.</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/35921"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Cölfen, Helmut</dc:contributor> <dc:creator>Schlaad, Helmut</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/35921/3/Hardy_0-372725.pdf"/> <dc:contributor>Torres-Rendon, Jose Guillermo</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-11-15T14:05:16Z</dcterms:available> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/35921/3/Hardy_0-372725.pdf"/> <dc:creator>Walther, Andreas</dc:creator> <dc:contributor>Leal-Egaña, Aldo</dc:contributor> <dc:creator>Hardy, John G.</dc:creator> </rdf:Description> </rdf:RDF>
Dateiabrufe seit 15.11.2016 (Informationen über die Zugriffsstatistik)
| Hardy_0-372725.pdf | 210 |
Das Dokument erscheint in:
KOPS Suche
Stöbern
Mein Benutzerkonto
