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IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity

IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity

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Prüfsumme: MD5:e6b7af7bb6a2a487908ca2f79dfe0d99

COHEN, Idan, Peleg RIDER, Elena VORONOV, Martin TOMAS, Cicerone TUDOR, Mareike WEGNER, Lydia BRONDANI, Elisa FERRANDO-MAY, Ron N. APTE, Robert SCHNEIDER, 2015. IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. In: Scientific Reports. 5, 14756. eISSN 2045-2322

@article{Cohen2015-10-06damag-35182, title={IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity}, year={2015}, doi={10.1038/srep14756}, volume={5}, journal={Scientific Reports}, author={Cohen, Idan and Rider, Peleg and Voronov, Elena and Tomas, Martin and Tudor, Cicerone and Wegner, Mareike and Brondani, Lydia and Ferrando-May, Elisa and Apte, Ron N. and Schneider, Robert}, note={Article Number: 14756} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/35182"> <dc:creator>Brondani, Lydia</dc:creator> <dc:creator>Apte, Ron N.</dc:creator> <dc:contributor>Brondani, Lydia</dc:contributor> <dcterms:abstract xml:lang="eng">Environmental signals can be translated into chromatin changes, which alter gene expression. Here we report a novel concept that cells can signal chromatin damage from the nucleus back to the surrounding tissue through the cytokine interleukin-1alpha (IL-1α). Thus, in addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, IL-1α could directly sense DNA damage and act as signal for genotoxic stress without loss of cell integrity. Here we demonstrate localization of the cytokine to DNA-damage sites and its subsequent secretion. Interestingly, its nucleo-cytosolic shuttling after DNA damage sensing is regulated by histone deacetylases (HDAC) and IL-1α acetylation. To demonstrate the physiological significance of this newly discovered mechanism, we used IL-1α knockout mice and show that IL-1α signaling after UV skin irradiation and DNA damage is important for triggering a sterile inflammatory cascade in vivo that contributes to efficient tissue repair and wound healing.</dcterms:abstract> <dc:contributor>Apte, Ron N.</dc:contributor> <dc:contributor>Schneider, Robert</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-09-08T13:15:09Z</dc:date> <dcterms:issued>2015-10-06</dcterms:issued> <dc:creator>Wegner, Mareike</dc:creator> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-09-08T13:15:09Z</dcterms:available> <dcterms:title>IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity</dcterms:title> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/35182"/> <dc:contributor>Ferrando-May, Elisa</dc:contributor> <dc:contributor>Rider, Peleg</dc:contributor> <dc:creator>Tudor, Cicerone</dc:creator> <dc:contributor>Cohen, Idan</dc:contributor> <dc:contributor>Tudor, Cicerone</dc:contributor> <dc:creator>Ferrando-May, Elisa</dc:creator> <dc:creator>Rider, Peleg</dc:creator> <dc:creator>Tomas, Martin</dc:creator> <dc:contributor>Tomas, Martin</dc:contributor> <dc:creator>Cohen, Idan</dc:creator> <dc:creator>Voronov, Elena</dc:creator> <dc:contributor>Wegner, Mareike</dc:contributor> <dc:creator>Schneider, Robert</dc:creator> <dc:contributor>Voronov, Elena</dc:contributor> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 08.09.2016 (Informationen über die Zugriffsstatistik)

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