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Macrophage Superoxide Anion Production in Essential Hypertension : Associations With Biological and Psychological Cardiovascular Risk Factors

Macrophage Superoxide Anion Production in Essential Hypertension : Associations With Biological and Psychological Cardiovascular Risk Factors

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ZUCCARELLA-HACKL, Claudia, Roland VON KÄNEL, Livia THOMAS, Mark HAUSER, Ulrike KUEBLER, Hans Rudolf WIDMER, Petra H. WIRTZ, 2016. Macrophage Superoxide Anion Production in Essential Hypertension : Associations With Biological and Psychological Cardiovascular Risk Factors. In: Psychosomatic Medicine. 78(6), pp. 750-757. ISSN 0033-3174. eISSN 1534-7796

@article{Zuccarella-Hackl2016Macro-35097, title={Macrophage Superoxide Anion Production in Essential Hypertension : Associations With Biological and Psychological Cardiovascular Risk Factors}, year={2016}, doi={10.1097/PSY.0000000000000324}, number={6}, volume={78}, issn={0033-3174}, journal={Psychosomatic Medicine}, pages={750--757}, author={Zuccarella-Hackl, Claudia and von Känel, Roland and Thomas, Livia and Hauser, Mark and Kuebler, Ulrike and Widmer, Hans Rudolf and Wirtz, Petra H.} }

Zuccarella-Hackl, Claudia Hauser, Mark 2016-09-02T08:36:45Z Kuebler, Ulrike 2016 Macrophage Superoxide Anion Production in Essential Hypertension : Associations With Biological and Psychological Cardiovascular Risk Factors Thomas, Livia Zuccarella-Hackl, Claudia Hauser, Mark von Känel, Roland eng Wirtz, Petra H. Thomas, Livia Objective:<br /><br />Essential hypertension is an important risk factor for coronary artery disease and its underlying process atherosclerosis, but involved mechanisms are not fully understood. Both macrophages and superoxide anions have been proposed to play a major role in the pathogenesis of atherosclerosis. In the present study, we investigated whether macrophages of individuals with hypertension show higher nicotinamide adenine dinucleotide phosphate oxidase–derived superoxide anion production compared with normotensive individuals. Furthermore, we examined associations between macrophage superoxide anion production and the psychological factors depression and chronic stress independent from hypertension status.<br /><br />Methods:<br />We studied 30 hypertensive (mean [standard deviation] = 48.7 [2.4] years) and 30 age-matched normotensive men (mean [standard deviation] = 48.6 [2.4] years). We assessed macrophage superoxide anion production using the WST-1 assay. The assay is based on the chemical reduction of the cell-impermeative tetrazolium salt WST-1 by superoxide anions that are produced by activated human ex vivo isolated monocyte-derived macrophages. We further evaluated whether chronic stress or depressive symptom severity was associated with macrophage superoxide anion production. All analyses were adjusted for potential confounders.<br /><br />Results:<br />Individuals with hypertension showed higher superoxide anion production compared with normotensive individuals (F(1,58) = 11.56, p = .001). Complementary analyses using mean arterial blood pressure as a continuous measure revealed that higher mean arterial pressure correlated significantly with higher WST-1 reduction (ß = .38, p = .003, [DELTA]R2 = .145). These results remained significant when controlling for potential confounding influences. Chronic stress was related to higher WST-1 reduction scores, but this association was not statistically significant (ß = .24, p = .067, [DELTA]R2 = .053); depression levels were not significantly associated with WST-1 reduction scores (p = .24).<br /><br />Conclusions:<br />Our results indicate higher macrophage superoxide anion production in individuals with hypertension compared with normotensive individuals. This may suggest a mechanism underlying cardiovascular risk with hypertension. Widmer, Hans Rudolf Kuebler, Ulrike Widmer, Hans Rudolf Wirtz, Petra H. von Känel, Roland 2016-09-02T08:36:45Z

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