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Considering new methodologies in strategies for safety assessment of foods and food ingredients

Considering new methodologies in strategies for safety assessment of foods and food ingredients

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BLAAUBOER, Bas J., Alan R. BOOBIS, Bobbie BRADFORD, Andrew COCKBURN, Anne CONSTABLE, Mardas DANESHIAN, Gareth EDWARDS, Jossie A. GARTHOFF, Brett JEFFERY, Jeroen SCHUERMANS, 2016. Considering new methodologies in strategies for safety assessment of foods and food ingredients. In: Food and Chemical Toxicology. 91, pp. 19-35. eISSN 0278-6915. Available under: doi: 10.1016/j.fct.2016.02.019

@article{Blaauboer2016Consi-34594, title={Considering new methodologies in strategies for safety assessment of foods and food ingredients}, year={2016}, doi={10.1016/j.fct.2016.02.019}, volume={91}, journal={Food and Chemical Toxicology}, pages={19--35}, author={Blaauboer, Bas J. and Boobis, Alan R. and Bradford, Bobbie and Cockburn, Andrew and Constable, Anne and Daneshian, Mardas and Edwards, Gareth and Garthoff, Jossie A. and Jeffery, Brett and Schuermans, Jeroen} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/34594"> <dc:contributor>Bradford, Bobbie</dc:contributor> <dc:creator>Daneshian, Mardas</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-06-29T06:39:05Z</dc:date> <dc:contributor>Cockburn, Andrew</dc:contributor> <dc:contributor>Blaauboer, Bas J.</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/34594"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Garthoff, Jossie A.</dc:contributor> <dc:contributor>Schuermans, Jeroen</dc:contributor> <dc:creator>Garthoff, Jossie A.</dc:creator> <dc:creator>Cockburn, Andrew</dc:creator> <dc:creator>Blaauboer, Bas J.</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>2016</dcterms:issued> <dc:contributor>Edwards, Gareth</dc:contributor> <dc:contributor>Jeffery, Brett</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/34594/1/Blaauboer_-0-341067.pdf"/> <dc:language>eng</dc:language> <dc:contributor>Constable, Anne</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Jeffery, Brett</dc:creator> <dc:creator>Schuermans, Jeroen</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Bradford, Bobbie</dc:creator> <dc:creator>Boobis, Alan R.</dc:creator> <dc:creator>Edwards, Gareth</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/34594/1/Blaauboer_-0-341067.pdf"/> <dc:contributor>Boobis, Alan R.</dc:contributor> <dcterms:abstract xml:lang="eng">Toxicology and safety assessment are changing and require new strategies for evaluating risk that are less depending on apical toxicity endpoints in animal models and relying more on knowledge of the mechanism of toxicity. This manuscript describes a number of developments that could contribute to this change and implement this in a stepwise roadmap that can be applied for the evaluation of food and food ingredients. The roadmap was evaluated in four case studies by using literature and existing data. This preliminary evaluation was shown to be useful. However, this experience should be extended by including examples where experimental work needs to be included. To further implement these new insights in toxicology and safety assessment for the area of food and food ingredients, the recommendation is that stakeholders take action in addressing gaps in our knowledge, e.g. with regard to the applicability of the roadmap for mixtures and food matrices. Further development of the threshold of toxicological concern is needed, as well as cooperation with other sectors where similar schemes are under development. Moreover, a more comprehensive evaluation of the roadmap, also including the identification of the need for in vitro experimental work is recommended.</dcterms:abstract> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-06-29T06:39:05Z</dcterms:available> <dc:creator>Constable, Anne</dc:creator> <dc:contributor>Daneshian, Mardas</dc:contributor> <dcterms:title>Considering new methodologies in strategies for safety assessment of foods and food ingredients</dcterms:title> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 29.06.2016 (Informationen über die Zugriffsstatistik)

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