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Anaerobic Microbial Degradation of Hydrocarbons : from Enzymatic Reactions to the Environment

Anaerobic Microbial Degradation of Hydrocarbons : from Enzymatic Reactions to the Environment


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RABUS, Ralf, Matthias BOLL, Johann HEIDER, Rainer U. MECKENSTOCK, Wolfgang BUCKEL, Oliver EINSLE, Ulrich ERMLER, Peter M. H. KRONECK, Bernhard SCHINK, Heinz WILKES, 2016. Anaerobic Microbial Degradation of Hydrocarbons : from Enzymatic Reactions to the Environment. In: Journal of Molecular Microbiology and Biotechnology. 26(1-3), pp. 5-28. ISSN 1464-1801. eISSN 1660-2412

@article{Rabus2016Anaer-33892, title={Anaerobic Microbial Degradation of Hydrocarbons : from Enzymatic Reactions to the Environment}, year={2016}, doi={10.1159/000443997}, number={1-3}, volume={26}, issn={1464-1801}, journal={Journal of Molecular Microbiology and Biotechnology}, pages={5--28}, author={Rabus, Ralf and Boll, Matthias and Heider, Johann and Meckenstock, Rainer U. and Buckel, Wolfgang and Einsle, Oliver and Ermler, Ulrich and Kroneck, Peter M. H. and Schink, Bernhard and Wilkes, Heinz} }

Buckel, Wolfgang Boll, Matthias Schink, Bernhard Wilkes, Heinz Kroneck, Peter M. H. Hydrocarbons are abundant in anoxic environments and pose biochemical challenges to their anaerobic degradation by microorganisms. Within the framework of the Priority Program 1319, investigations funded by the Deutsche Forschungsgemeinschaft on the anaerobic microbial degradation of hydrocarbons ranged from isolation and enrichment of hitherto unknown hydrocarbon-degrading anaerobic microorganisms, discovery of novel reactions, detailed studies of enzyme mechanisms and structures to process-oriented in situ studies. Selected highlights from this program are collected in this synopsis, with more detailed information provided by theme-focused reviews of the special topic issue on 'Anaerobic biodegradation of hydrocarbons' [this issue, pp. 1-244]. The interdisciplinary character of the program, involving microbiologists, biochemists, organic chemists and environmental scientists, is best exemplified by the studies on alkyl-/arylalkylsuccinate synthases. Here, research topics ranged from in-depth mechanistic studies of archetypical toluene-activating benzylsuccinate synthase, substrate-specific phylogenetic clustering of alkyl-/arylalkylsuccinate synthases (toluene plus xylenes, p-cymene, p-cresol, 2-methylnaphthalene, n-alkanes), stereochemical and co-metabolic insights into n-alkane-activating (methylalkyl)succinate synthases to the discovery of bacterial groups previously unknown to possess alkyl-/arylalkylsuccinate synthases by means of functional gene markers and in situ field studies enabled by state-of-the-art stable isotope probing and fractionation approaches. Other topics are Mo-cofactor-dependent dehydrogenases performing O<sub>2</sub>-independent hydroxylation of hydrocarbons and alkyl side chains (ethylbenzene, p-cymene, cholesterol, n-hexadecane), degradation of p-alkylated benzoates and toluenes, glycyl radical-bearing 4-hydroxyphenylacetate decarboxylase, novel types of carboxylation reactions (for acetophenone, acetone, and potentially also benzene and naphthalene), W-cofactor-containing enzymes for reductive dearomatization of benzoyl-CoA (class II benzoyl-CoA reductase) in obligate anaerobes and addition of water to acetylene, fermentative formation of cyclohexanecarboxylate from benzoate, and methanogenic degradation of hydrocarbons. Boll, Matthias Heider, Johann Rabus, Ralf Buckel, Wolfgang Heider, Johann 2016 Meckenstock, Rainer U. Kroneck, Peter M. H. Ermler, Ulrich Einsle, Oliver Ermler, Ulrich Schink, Bernhard eng Einsle, Oliver Anaerobic Microbial Degradation of Hydrocarbons : from Enzymatic Reactions to the Environment Meckenstock, Rainer U. 2016-05-12T09:41:31Z Rabus, Ralf Wilkes, Heinz 2016-05-12T09:41:31Z

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