Getting it Right : How DNA Polymerases Select the Right Nucleotide

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LUDMANN, Samra, Andreas MARX, 2016. Getting it Right : How DNA Polymerases Select the Right Nucleotide. In: CHIMIA : International Journal for Chemistry. 70(3), pp. 203-206. ISSN 0009-4293. Available under: doi: 10.2533/chimia.2016.203

@article{Ludmann2016-03-30Getti-33766, title={Getting it Right : How DNA Polymerases Select the Right Nucleotide}, year={2016}, doi={10.2533/chimia.2016.203}, number={3}, volume={70}, issn={0009-4293}, journal={CHIMIA : International Journal for Chemistry}, pages={203--206}, author={Ludmann, Samra and Marx, Andreas} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:abstract xml:lang="eng">All living organisms are defined by their genetic code encrypted in their DNA. DNA polymerases are the enzymes that are responsible for all DNA syntheses occurring in nature. For DNA replication, repair and recombination these enzymes have to read the parental DNA and recognize the complementary nucleotide out of a pool of four structurally similar deoxynucleotide triphosphates (dNTPs) for a given template. The selection of the nucleotide is in accordance with the Watson-Crick rule. In this process the accuracy of DNA synthesis is crucial for the maintenance of the genome stability. However, to spur evolution a certain degree of freedom must be allowed. This brief review highlights the mechanistic basis for selecting the right nucleotide by DNA polymerases.</dcterms:abstract> <dc:contributor>Ludmann, Samra</dc:contributor> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="">2016-05-02T13:25:27Z</dcterms:available> <bibo:uri rdf:resource=""/> <dc:rights>terms-of-use</dc:rights> <dspace:hasBitstream rdf:resource=""/> <dcterms:isPartOf rdf:resource=""/> <dcterms:issued>2016-03-30</dcterms:issued> <dc:creator>Ludmann, Samra</dc:creator> <dc:date rdf:datatype="">2016-05-02T13:25:27Z</dc:date> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:isPartOfCollection rdf:resource=""/> <dc:creator>Marx, Andreas</dc:creator> <dcterms:rights rdf:resource=""/> <dc:contributor>Marx, Andreas</dc:contributor> <dcterms:hasPart rdf:resource=""/> <dcterms:title>Getting it Right : How DNA Polymerases Select the Right Nucleotide</dcterms:title> </rdf:Description> </rdf:RDF>

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