KOPS - The Institutional Repository of the University of Konstanz

Structure and Function of the Unusual Tungsten Enzymes Acetylene Hydratase and Class II Benzoyl-Coenzyme A Reductase

Structure and Function of the Unusual Tungsten Enzymes Acetylene Hydratase and Class II Benzoyl-Coenzyme A Reductase

Cite This

Files in this item

Checksum: MD5:b68f10f6223fb2b02e6d6208bd46d760

BOLL, Matthias, Oliver EINSLE, Ulrich ERMLER, Peter M. H. KRONECK, G. Matthias ULLMANN, 2016. Structure and Function of the Unusual Tungsten Enzymes Acetylene Hydratase and Class II Benzoyl-Coenzyme A Reductase. In: Journal of Molecular Microbiology and Biotechnology. 26(1-3), pp. 119-137. ISSN 1464-1801. eISSN 1660-2412. Available under: doi: 10.1159/000440805

@article{Boll2016-03-10Struc-33648, title={Structure and Function of the Unusual Tungsten Enzymes Acetylene Hydratase and Class II Benzoyl-Coenzyme A Reductase}, year={2016}, doi={10.1159/000440805}, number={1-3}, volume={26}, issn={1464-1801}, journal={Journal of Molecular Microbiology and Biotechnology}, pages={119--137}, author={Boll, Matthias and Einsle, Oliver and Ermler, Ulrich and Kroneck, Peter M. H. and Ullmann, G. Matthias} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/33648"> <dc:creator>Ullmann, G. Matthias</dc:creator> <dc:rights>terms-of-use</dc:rights> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Ermler, Ulrich</dc:contributor> <dc:language>eng</dc:language> <dcterms:title>Structure and Function of the Unusual Tungsten Enzymes Acetylene Hydratase and Class II Benzoyl-Coenzyme A Reductase</dcterms:title> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/33648/1/Boll_2-umhr4mb4d4kl4.pdf"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:creator>Boll, Matthias</dc:creator> <dc:creator>Einsle, Oliver</dc:creator> <dcterms:abstract xml:lang="eng">In biology, tungsten (W) is exclusively found in microbial enzymes bound to a bis-pyranopterin cofactor (bis-WPT). Previously known W enzymes catalyze redox oxo/hydroxyl transfer reactions by directly coordinating their substrates or products to the metal. They comprise the W-containing formate/formylmethanofuran dehydrogenases belonging to the dimethyl sulfoxide reductase (DMSOR) family and the aldehyde:ferredoxin oxidoreductase (AOR) families, which form a separate enzyme family within the Mo/W enzymes. In the last decade, initial insights into the structure and function of two unprecedented W enzymes were obtained: the acetaldehyde forming acetylene hydratase (ACH) belongs to the DMSOR and the class II benzoyl-coenzyme A (CoA) reductase (BCR) to the AOR family. The latter catalyzes the reductive dearomatization of benzoyl-CoA to a cyclic diene. Both are key enzymes in the degradation of acetylene (ACH) or aromatic compounds (BCR) in strictly anaerobic bacteria. They are unusual in either catalyzing a nonredox reaction (ACH) or a redox reaction without coordinating the substrate or product to the metal (BCR). In organic chemical synthesis, analogous reactions require totally nonphysiological conditions depending on Hg2+ (acetylene hydration) or alkali metals (benzene ring reduction). The structural insights obtained pave the way for biological or biomimetic approaches to basic reactions in organic chemistry.</dcterms:abstract> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Kroneck, Peter M. H.</dc:creator> <dcterms:issued>2016-03-10</dcterms:issued> <dc:creator>Ermler, Ulrich</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/33648/1/Boll_2-umhr4mb4d4kl4.pdf"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-04-21T09:19:00Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-04-21T09:19:00Z</dc:date> <dc:contributor>Einsle, Oliver</dc:contributor> <dc:contributor>Kroneck, Peter M. H.</dc:contributor> <dc:contributor>Ullmann, G. Matthias</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/33648"/> <dc:contributor>Boll, Matthias</dc:contributor> </rdf:Description> </rdf:RDF>

Downloads since Apr 21, 2016 (Information about access statistics)

Boll_2-umhr4mb4d4kl4.pdf 77

This item appears in the following Collection(s)

Search KOPS


Browse

My Account