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Study of the Chemoselectivity of Multicomponent Heterocyclizations Involving 3-Amino-1,2,4-triazole and Pyruvic Acids as Key Reagents, and Biological Activity of the Reaction Products

Study of the Chemoselectivity of Multicomponent Heterocyclizations Involving 3-Amino-1,2,4-triazole and Pyruvic Acids as Key Reagents, and Biological Activity of the Reaction Products

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MURLYKINA, Maryna V., Yana I. SAKHNO, Sergey M. DESENKO, Svetlana V. SHISHKINA, Oleg V. SHISHKIN, Dmytro O. SYSOIEV, Maryna N. KORNET, Dominique SCHOLS, Jan L. GOEMAN, Johan VAN DER EYCKEN, Erik V. VAN DER EYCKEN, Valentin A. CHEBANOV, 2015. Study of the Chemoselectivity of Multicomponent Heterocyclizations Involving 3-Amino-1,2,4-triazole and Pyruvic Acids as Key Reagents, and Biological Activity of the Reaction Products. In: European Journal of Organic Chemistry. 2015(20), pp. 4481-4492. ISSN 1434-193X. eISSN 0365-5490. Available under: doi: 10.1002/ejoc.201500469

@article{Murlykina2015Study-32599, title={Study of the Chemoselectivity of Multicomponent Heterocyclizations Involving 3-Amino-1,2,4-triazole and Pyruvic Acids as Key Reagents, and Biological Activity of the Reaction Products}, year={2015}, doi={10.1002/ejoc.201500469}, number={20}, volume={2015}, issn={1434-193X}, journal={European Journal of Organic Chemistry}, pages={4481--4492}, author={Murlykina, Maryna V. and Sakhno, Yana I. and Desenko, Sergey M. and Shishkina, Svetlana V. and Shishkin, Oleg V. and Sysoiev, Dmytro O. and Kornet, Maryna N. and Schols, Dominique and Goeman, Jan L. and Van der Eycken, Johan and Van der Eycken, Erik V. and Chebanov, Valentin A.} }

Schols, Dominique eng Desenko, Sergey M. Van der Eycken, Erik V. Goeman, Jan L. Van der Eycken, Johan Chebanov, Valentin A. Kornet, Maryna N. Sysoiev, Dmytro O. Sysoiev, Dmytro O. 2016-01-15T08:47:05Z Schols, Dominique 2016-01-15T08:47:05Z Shishkina, Svetlana V. Shishkin, Oleg V. Study of the Chemoselectivity of Multicomponent Heterocyclizations Involving 3-Amino-1,2,4-triazole and Pyruvic Acids as Key Reagents, and Biological Activity of the Reaction Products 2015 Desenko, Sergey M. Van der Eycken, Erik V. Murlykina, Maryna V. Sakhno, Yana I. Murlykina, Maryna V. Goeman, Jan L. Sakhno, Yana I. Kornet, Maryna N. Shishkin, Oleg V. Chebanov, Valentin A. Shishkina, Svetlana V. Van der Eycken, Johan Three-component reactions involving 3-amino-1,2,4-triazole, aldehydes, including salicylic aldehydes, and pyruvic acids were studied in detail. The reaction pathway and products of the heterocyclizations could be changed by variation of the reaction parameters. The broad antimicrobial activity of the products was also studied. Compound 9d showed specific anti-influenza virus (A/H1N1) activity, with an IC<sub>50</sub> of 0.57 μM and a CC<sub>50</sub> of >100 μM.

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