Type of Publication: | Journal article |
Publication status: | Published |
Author: | Mundt, Sarah; Engelhardt, Britta; Kirk, Christopher J.; Groettrup, Marcus; Basler, Michael |
Year of publication: | 2016 |
Published in: | European Journal of Immunology ; 46 (2016), 1. - pp. 104-113. - ISSN 0014-2980. - eISSN 1521-4141 |
Pubmed ID: | 26464284 |
DOI (citable link): | https://dx.doi.org/10.1002/eji.201545578 |
Summary: |
In addition to antigen processing, immunoproteasomes were recently shown to exert additional functions influencing cytokine production by monocytes and T cells, T helper cell differentiation, and T-cell survival. Moreover, selective inhibition of the immunoproteasome subunit LMP7 ameliorated symptoms of autoimmune diseases including CD4(+) T cell mediated experimental autoimmune encephalomyelitis (EAE). In this study, we show that LMP7 also plays a crucial role in the pathogenesis of lymphocytic choriomeningitis virus (LCMV)-induced meningitis mediated by cytotoxic T cells (CTLs). Mice lacking functional LMP7 display delayed and reduced clinical signs of disease accompanied by a strongly decreased inflammatory infiltration into the brain. Interestingly, we found that selective inhibition and genetic deficiency of LMP7 affect the pathogenesis of LCMV-induced meningitis in a distinct manner. Our findings support the important role of LMP7 in inflammatory disorders and suggest immunoproteasome inhibition as a novel strategy against inflammation-induced neuropathology in the CNS. This article is protected by copyright. All rights reserved.
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Subject (DDC): | 570 Biosciences, Biology |
Bibliography of Konstanz: | Yes |
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MUNDT, Sarah, Britta ENGELHARDT, Christopher J. KIRK, Marcus GROETTRUP, Michael BASLER, 2016. Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. In: European Journal of Immunology. 46(1), pp. 104-113. ISSN 0014-2980. eISSN 1521-4141. Available under: doi: 10.1002/eji.201545578
@article{Mundt2016Inhib-32418, title={Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis}, year={2016}, doi={10.1002/eji.201545578}, number={1}, volume={46}, issn={0014-2980}, journal={European Journal of Immunology}, pages={104--113}, author={Mundt, Sarah and Engelhardt, Britta and Kirk, Christopher J. and Groettrup, Marcus and Basler, Michael} }
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