KOPS - Das Institutionelle Repositorium der Universität Konstanz

Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis

Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

MUNDT, Sarah, Britta ENGELHARDT, Christopher J. KIRK, Marcus GROETTRUP, Michael BASLER, 2016. Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. In: European Journal of Immunology. 46(1), pp. 104-113. ISSN 0014-2980. eISSN 1521-4141. Available under: doi: 10.1002/eji.201545578

@article{Mundt2016Inhib-32418, title={Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis}, year={2016}, doi={10.1002/eji.201545578}, number={1}, volume={46}, issn={0014-2980}, journal={European Journal of Immunology}, pages={104--113}, author={Mundt, Sarah and Engelhardt, Britta and Kirk, Christopher J. and Groettrup, Marcus and Basler, Michael} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/32418"> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">In addition to antigen processing, immunoproteasomes were recently shown to exert additional functions influencing cytokine production by monocytes and T cells, T helper cell differentiation, and T-cell survival. Moreover, selective inhibition of the immunoproteasome subunit LMP7 ameliorated symptoms of autoimmune diseases including CD4(+) T cell mediated experimental autoimmune encephalomyelitis (EAE). In this study, we show that LMP7 also plays a crucial role in the pathogenesis of lymphocytic choriomeningitis virus (LCMV)-induced meningitis mediated by cytotoxic T cells (CTLs). Mice lacking functional LMP7 display delayed and reduced clinical signs of disease accompanied by a strongly decreased inflammatory infiltration into the brain. Interestingly, we found that selective inhibition and genetic deficiency of LMP7 affect the pathogenesis of LCMV-induced meningitis in a distinct manner. Our findings support the important role of LMP7 in inflammatory disorders and suggest immunoproteasome inhibition as a novel strategy against inflammation-induced neuropathology in the CNS. This article is protected by copyright. All rights reserved.</dcterms:abstract> <dc:creator>Mundt, Sarah</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-12-15T14:09:06Z</dcterms:available> <dc:creator>Basler, Michael</dc:creator> <dc:language>eng</dc:language> <dc:creator>Kirk, Christopher J.</dc:creator> <dc:contributor>Groettrup, Marcus</dc:contributor> <dcterms:title>Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis</dcterms:title> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Basler, Michael</dc:contributor> <dc:contributor>Kirk, Christopher J.</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-12-15T14:09:06Z</dc:date> <dcterms:issued>2016</dcterms:issued> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Engelhardt, Britta</dc:creator> <dc:contributor>Mundt, Sarah</dc:contributor> <dc:creator>Groettrup, Marcus</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Engelhardt, Britta</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/32418"/> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto