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Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease

Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease

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Prüfsumme: MD5:73e30aabe638cc94104148fbc735b0d9

HERRMANN, Valerie L., Carmen HARTMAYER, Oliver PLANZ, Marcus GROETTRUP, 2015. Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease. In: Journal of Controlled Release. 216, pp. 121-131. ISSN 0168-3659. eISSN 1873-4995

@article{Herrmann2015Cytot-32304, title={Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease}, year={2015}, doi={10.1016/j.jconrel.2015.08.019}, volume={216}, issn={0168-3659}, journal={Journal of Controlled Release}, pages={121--131}, author={Herrmann, Valerie L. and Hartmayer, Carmen and Planz, Oliver and Groettrup, Marcus} }

Planz, Oliver Hartmayer, Carmen Herrmann, Valerie L. Planz, Oliver Hartmayer, Carmen 2015-12-02T13:24:26Z Groettrup, Marcus 2015 Current influenza virus vaccines aim to elicit antibodies directed toward viral surface glycoproteins, which however are prone to antigenic drift. Cytotoxic T lymphocytes (CTLs) can exhibit heterosubtypic immunity against most influenza A viruses. In our study, we encapsulated the highly conserved, immunodominant, HLA-A*0201 restricted epitope from the influenza virus matrix protein M1<sub>58-66</sub> together with TLR ligands in biodegradable poly(d,l-lactide-co-glycolide) (PLGA) microspheres. Subcutaneous immunization of transgenic mice expressing chimeric HLA-A*0201 molecules with these microspheres induced a strong and sustained CTL response which sufficed to prevent replication of a recombinant vaccinia virus expressing the influenza A virus (IAV) matrix protein but not the replication of IAV in the lung. However, subcutaneous priming followed by intranasal boosting with M158-66 bearing PLGA microspheres was able to induce vigorous CTL responses both in the lung and spleen of mice which interfered with IAV replication, weight loss, and infection-related death. Taken together, vaccination with well-defined and highly conserved IAV-derived CTL epitopes encapsulated into clinically compatible PLGA microspheres contribute to the control of influenza A virus infections. The promptitude and broad reactivity of the CTL response may help to attenuate pandemic outbreaks of influenza viruses. 2015-12-02T13:24:26Z eng Groettrup, Marcus Herrmann, Valerie L. Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease

Dateiabrufe seit 02.12.2015 (Informationen über die Zugriffsstatistik)

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