Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E2

Kurzanzeige
dc.contributor.authorBruckner, Markusdeu
dc.contributor.authorDickel, Denisedeu
dc.contributor.authorSinger, Evadeu
dc.contributor.authorLegler, Daniel F.
dc.date.accessioned2013-06-11T13:57:56Zdeu
dc.date.available2013-06-11T13:57:56Zdeu
dc.date.issued2012-03
dc.description.abstractDendritic cells (DCs) are key in regulating immune responses. DCs reside in tissues facing the environment and sample their surrounding for pathogens. Upon pathogen encounter, DCs mature and migrate into secondary lymphoid organs. Distinct maturation signals dictate the ability of DCs to produce distinct patterns of chemokines that orchestrate immunity. Prostaglandin E2 (PGE2) is produced during inflammation and modulates DC functions. We demonstrate that PGE2 modulates distinct chemokine expression patterns of human monocyte-derived (Mo) DCs upon maturation with various stimuli. PGE2 dampened early production of the inflammatory chemokines CCL2, CCL4, CCL5 and attenuated the expression of the T cell attractant CXCL10. In contrast, PGE2 enhanced CXCL8 production early during maturation, whereas CXCL16 levels were continuously elevated, contributing to innate immune cell recruitment. Moreover, PGE2 induces transcription of the homeostatic chemokines CCL17 and CCL22. Finally, mature MoDCs produced the homing chemokine CCL19 and its expression was down-regulated by PGE2.eng
dc.description.versionpublished
dc.identifier.citationCellular Immunology ; 276 (2012), 1-2. - S. 52-58deu
dc.identifier.doi10.1016/j.cellimm.2012.03.008deu
dc.identifier.pmid22565056
dc.identifier.ppn483405647
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/23561
dc.language.isoengdeu
dc.legacy.dateIssued2013-06-11deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectHuman monocyte-derived dendritic cellsdeu
dc.subjectchemokinesdeu
dc.subjectprostaglandin E2deu
dc.subject.ddc570deu
dc.titleDistinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E<sub>2</sub>eng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Bruckner2012-03Disti-23561,
  year={2012},
  doi={10.1016/j.cellimm.2012.03.008},
  title={Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E<sub>2</sub>},
  number={1-2},
  volume={276},
  issn={0008-8749},
  journal={Cellular Immunology},
  pages={52--58},
  author={Bruckner, Markus and Dickel, Denise and Singer, Eva and Legler, Daniel F.}
}
kops.citation.iso690BRUCKNER, Markus, Denise DICKEL, Eva SINGER, Daniel F. LEGLER, 2012. Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E2. In: Cellular Immunology. 2012, 276(1-2), pp. 52-58. ISSN 0008-8749. eISSN 1090-2163. Available under: doi: 10.1016/j.cellimm.2012.03.008deu
kops.citation.iso690BRUCKNER, Markus, Denise DICKEL, Eva SINGER, Daniel F. LEGLER, 2012. Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E2. In: Cellular Immunology. 2012, 276(1-2), pp. 52-58. ISSN 0008-8749. eISSN 1090-2163. Available under: doi: 10.1016/j.cellimm.2012.03.008eng
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    <dcterms:abstract xml:lang="eng">Dendritic cells (DCs) are key in regulating immune responses. DCs reside in tissues facing the environment and sample their surrounding for pathogens. Upon pathogen encounter, DCs mature and migrate into secondary lymphoid organs. Distinct maturation signals dictate the ability of DCs to produce distinct patterns of chemokines that orchestrate immunity. Prostaglandin E&lt;sub&gt;2&lt;/sub&gt; (PGE&lt;sub&gt;2&lt;/sub&gt;) is produced during inflammation and modulates DC functions. We demonstrate that PGE&lt;sub&gt;2&lt;/sub&gt; modulates distinct chemokine expression patterns of human monocyte-derived (Mo) DCs upon maturation with various stimuli. PGE&lt;sub&gt;2&lt;/sub&gt; dampened early production of the inflammatory chemokines CCL2, CCL4, CCL5 and attenuated the expression of the T cell attractant CXCL10. In contrast, PGE&lt;sub&gt;2&lt;/sub&gt; enhanced CXCL8 production early during maturation, whereas CXCL16 levels were continuously elevated, contributing to innate immune cell recruitment. Moreover, PGE&lt;sub&gt;2&lt;/sub&gt; induces transcription of the homeostatic chemokines CCL17 and CCL22. Finally, mature MoDCs produced the homing chemokine CCL19 and its expression was down-regulated by PGE&lt;sub&gt;2&lt;/sub&gt;.</dcterms:abstract>
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kops.description.openAccessopenaccessgreen
kops.identifier.nbnurn:nbn:de:bsz:352-235610deu
kops.sourcefieldCellular Immunology. 2012, <b>276</b>(1-2), pp. 52-58. ISSN 0008-8749. eISSN 1090-2163. Available under: doi: 10.1016/j.cellimm.2012.03.008deu
kops.sourcefield.plainCellular Immunology. 2012, 276(1-2), pp. 52-58. ISSN 0008-8749. eISSN 1090-2163. Available under: doi: 10.1016/j.cellimm.2012.03.008deu
kops.sourcefield.plainCellular Immunology. 2012, 276(1-2), pp. 52-58. ISSN 0008-8749. eISSN 1090-2163. Available under: doi: 10.1016/j.cellimm.2012.03.008eng
kops.submitter.emailoleg.kozlov@uni-konstanz.dedeu
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source.bibliographicInfo.fromPage52
source.bibliographicInfo.issue1-2
source.bibliographicInfo.toPage58
source.bibliographicInfo.volume276
source.identifier.eissn1090-2163
source.identifier.issn0008-8749
source.periodicalTitleCellular Immunology

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