@article{Popp2012Impac-22635,
  year={2012},
  doi={10.1155/2012/102423},
  title={Impact of β-turn sequence on β-hairpin dynamics studied with infrared-detected temperature jump},
  volume={27},
  issn={0712-4813},
  journal={Spectroscopy: An International Journal},
  pages={557--564},
  author={Popp, Alexander and Wu, Ling and Keiderling, Timothy A. and Hauser, Karin}
}

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    <dc:contributor>Popp, Alexander</dc:contributor>
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    <dc:creator>Popp, Alexander</dc:creator>
    <dc:creator>Keiderling, Timothy A.</dc:creator>
    <dcterms:bibliographicCitation>Spectroscopy ; 27 (2012), 5/6. - S. 557-564</dcterms:bibliographicCitation>
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    <dc:creator>Hauser, Karin</dc:creator>
    <dc:creator>Wu, Ling</dc:creator>
    <dcterms:title>Impact of β-turn sequence on β-hairpin dynamics studied with infrared-detected temperature jump</dcterms:title>
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    <dc:contributor>Wu, Ling</dc:contributor>
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    <dcterms:issued>2012</dcterms:issued>
    <dc:contributor>Hauser, Karin</dc:contributor>
    <dc:language>eng</dc:language>
    <dcterms:abstract xml:lang="eng">Folding dynamics for β-structure loss and disordered structure gain were studied in a model β-hairpin peptide based on Cochran’s tryptophan zipper peptide Trpzip2, but with an altered Thr-Gly (TG) turn sequence, that is, SWTWETGKWTWK, using laser-induced temperature-jump (T-jump) kinetics with IR detection.  As has been shown previously, the TG turn sequence reduces the thermodynamic β-hairpin stability as compared to the Asn-Gly sequence used in Trpzip2 (TZ2-NG). In this study, we found that the TG-turn slows down the overall relaxation dynamics as compared to TZ2-NG, which were studied at higher temperatures where the time constants show little difference between relaxation of the β-strand and the disordered conformation. These time constants become equivalent at lower temperatures for TZ2-TG than was seen for TZ2-NG. The correlation of thermodynamic stability and rates of relaxation suggests that the change from NG to TG turn results in a slowing of folding, lower k&lt;sub&gt;f&lt;/sub&gt;, with less change of the unfolding rate, k&lt;sub&gt;u&lt;/sub&gt;, assuming two state behavior at higher temperatures.</dcterms:abstract>
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    <dc:contributor>Keiderling, Timothy A.</dc:contributor>
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