Publikation:

Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro

Lade...
Vorschaubild

Dateien

Moradpour_221455.pdf
Moradpour_221455.pdfGröße: 151.37 KBDownloads: 188

Datum

2001

Autor:innen

Moradpour, Darius
Grabscheid, Benno
Kammer, Andreas R.
Blum, Hubert E.
Cerny, Andreas

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Hepatology. 2001, 33(5), pp. 1282-1287. ISSN 0270-9139. eISSN 1527-3350. Available under: doi: 10.1053/jhep.2001.23793

Zusammenfassung

Hepatitis C virus (HCV) infection takes a chronic course in the majority of patients. The mechanisms underlying the evasion of the host immune response and viral persistence are poorly understood. In this context, we investigated interactions of HCV proteins with major histocompatibility complex (MHC) class I processing and presentation pathways using cell lines that allow the tetracycline-regulated expression of viral structural and nonstructural proteins. These well-characterized inducible cell lines were found to efficiently process and present endogenously synthesized HCV proteins via MHC class I. Functional MHC class I cell-surface expression and intracellular proteasome activity were not affected by the expression of HCV proteins. These results suggest that viral evasion of the host immune response does not involve interactions of HCV with MHC class I processing and presentation. Other mechanisms, such as interference with the interferon system, may be operative in HCV infection, leading to viral persistence.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690MORADPOUR, Darius, Benno GRABSCHEID, Andreas R. KAMMER, Gunter SCHMIDTKE, Marcus GRÖTTRUP, Hubert E. BLUM, Andreas CERNY, 2001. Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro. In: Hepatology. 2001, 33(5), pp. 1282-1287. ISSN 0270-9139. eISSN 1527-3350. Available under: doi: 10.1053/jhep.2001.23793
BibTex
@article{Moradpour2001-05Expre-22145,
  year={2001},
  doi={10.1053/jhep.2001.23793},
  title={Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro},
  number={5},
  volume={33},
  issn={0270-9139},
  journal={Hepatology},
  pages={1282--1287},
  author={Moradpour, Darius and Grabscheid, Benno and Kammer, Andreas R. and Schmidtke, Gunter and Gröttrup, Marcus and Blum, Hubert E. and Cerny, Andreas}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/22145">
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Cerny, Andreas</dc:contributor>
    <dc:contributor>Grabscheid, Benno</dc:contributor>
    <dc:creator>Schmidtke, Gunter</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-28T10:13:52Z</dcterms:available>
    <dc:contributor>Schmidtke, Gunter</dc:contributor>
    <dcterms:abstract xml:lang="eng">Hepatitis C virus (HCV) infection takes a chronic course in the majority of patients. The mechanisms underlying the evasion of the host immune response and viral persistence are poorly understood. In this context, we investigated interactions of HCV proteins with major histocompatibility complex (MHC) class I processing and presentation pathways using cell lines that allow the tetracycline-regulated expression of viral structural and nonstructural proteins. These well-characterized inducible cell lines were found to efficiently process and present endogenously synthesized HCV proteins via MHC class I. Functional MHC class I cell-surface expression and intracellular proteasome activity were not affected by the expression of HCV proteins. These results suggest that viral evasion of the host immune response does not involve interactions of HCV with MHC class I processing and presentation. Other mechanisms, such as interference with the interferon system, may be operative in HCV infection, leading to viral persistence.</dcterms:abstract>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:bibliographicCitation>Hepatology ; 33 (2001), 5. - S. 1282-1287</dcterms:bibliographicCitation>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-28T10:13:52Z</dc:date>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Blum, Hubert E.</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Gröttrup, Marcus</dc:contributor>
    <dc:creator>Gröttrup, Marcus</dc:creator>
    <dc:creator>Kammer, Andreas R.</dc:creator>
    <dc:creator>Moradpour, Darius</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Moradpour, Darius</dc:contributor>
    <dc:language>eng</dc:language>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/22145/2/Moradpour_221455.pdf"/>
    <dc:creator>Cerny, Andreas</dc:creator>
    <dcterms:issued>2001-05</dcterms:issued>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22145"/>
    <dcterms:title>Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro</dcterms:title>
    <dc:contributor>Blum, Hubert E.</dc:contributor>
    <dc:creator>Grabscheid, Benno</dc:creator>
    <dc:contributor>Kammer, Andreas R.</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/22145/2/Moradpour_221455.pdf"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen