Antiparallel Arrangement of the Helices of Vesicle-Bound α-Synuclein

Kurzanzeige
dc.contributor.authorDrescher, Malte
dc.contributor.authorVeldhuis, Gertjandeu
dc.contributor.authorRooijen, Bart D. vandeu
dc.contributor.authorMilikisyants, Sergeydeu
dc.contributor.authorSubramaniam, Vinod
dc.contributor.authorHuber, Martinadeu
dc.date.accessioned2011-03-22T17:55:17Zdeu
dc.date.available2011-03-22T17:55:17Zdeu
dc.date.issued2008deu
dc.description.abstractalpha-Synuclein (alpha S) is the main component of Lewy bodies from Parkinson's disease. That alpha S binds to membranes is known, but the conformation it adopts is still unclear. Pulsed EPR on doubly spin-labeled variants of alpha S sheds light on the most likely structure. For alpha S bound to vesicles large enough to accommodate also the extended conformation, an antiparallel helix conformation is found. This suggests that the bent structure shown is the preferred conformation of alpha S on membranes.eng
dc.description.versionpublished
dc.identifier.citationPubl. in: Journal of the American Chemical Society 130 (2008), 25, pp. 7796-7797deu
dc.identifier.doi10.1021/ja801594s
dc.identifier.pmid18512917
dc.identifier.ppn1842028383
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/1110
dc.language.isoengdeu
dc.legacy.dateIssued2010deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectdodecyl-sulfate micellesdeu
dc.subjectparkinsons-diseasedeu
dc.subjectspectroscopydeu
dc.subjectdynamicsdeu
dc.subjectbindingdeu
dc.subjectproteindeu
dc.subjectEPRdeu
dc.subjectassociationdeu
dc.subjectmembranesdeu
dc.subjectvariantsdeu
dc.subject.ddc540deu
dc.titleAntiparallel Arrangement of the Helices of Vesicle-Bound α-Synucleineng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
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  title={Antiparallel Arrangement of the Helices of Vesicle-Bound α-Synuclein},
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  volume={130},
  issn={0002-7863},
  journal={Journal of the American Chemical Society},
  pages={7796--7797},
  author={Drescher, Malte and Veldhuis, Gertjan and Rooijen, Bart D. van and Milikisyants, Sergey and Subramaniam, Vinod and Huber, Martina}
}
kops.citation.iso690DRESCHER, Malte, Gertjan VELDHUIS, Bart D. van ROOIJEN, Sergey MILIKISYANTS, Vinod SUBRAMANIAM, Martina HUBER, 2008. Antiparallel Arrangement of the Helices of Vesicle-Bound α-Synuclein. In: Journal of the American Chemical Society. 2008, 130(25), pp. 7796-7797. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja801594sdeu
kops.citation.iso690DRESCHER, Malte, Gertjan VELDHUIS, Bart D. van ROOIJEN, Sergey MILIKISYANTS, Vinod SUBRAMANIAM, Martina HUBER, 2008. Antiparallel Arrangement of the Helices of Vesicle-Bound α-Synuclein. In: Journal of the American Chemical Society. 2008, 130(25), pp. 7796-7797. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja801594seng
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