Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance

Kurzanzeige
dc.contributor.authorBoccardi, Marina
dc.contributor.authorBocchetta, Martina
dc.contributor.authorApostolova, Liana G.
dc.contributor.authorBarnes, Josephine
dc.contributor.authorBartzokis, George
dc.contributor.authorCorbetta, Gabriele
dc.contributor.authorDeCarli, Charles
dc.contributor.authordeToledo-Morrell, Leyla
dc.contributor.authorPruessner, Jens C.
dc.contributor.authorFrisoni, Giovanni B.
dc.date.accessioned2017-04-18T07:21:28Z
dc.date.available2017-04-18T07:21:28Z
dc.date.issued2015-02eng
dc.description.abstractBackground

This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.

Methods

The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.

Results

Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer’s disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.

Discussion

Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.		eng
dc.description.versionpublishedeng
dc.identifier.doi10.1016/j.jalz.2014.02.009eng
dc.identifier.pmid25130658eng
dc.identifier.ppn1663446113
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/38496
dc.language.isoengeng
dc.rightsterms-of-use
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/
dc.subjectHippocampus; Atrophy; Volumetry; Manual segmentation; Harmonization; Anatomical landmarks; Delphi procedure; Alzheimer's disease; Medial temporal lobe; Hippocampal atrophy; Magnetic resonance; Neuroimaging; Standard operational procedures; Enrichment; MCI; Reliabilityeng
dc.subject.ddc150eng
dc.titleDelphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonanceeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Boccardi2015-02Delph-38496,
  year={2015},
  doi={10.1016/j.jalz.2014.02.009},
  title={Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance},
  number={2},
  volume={11},
  issn={1552-5260},
  journal={Alzheimer's & Dementia},
  pages={126--138},
  author={Boccardi, Marina and Bocchetta, Martina and Apostolova, Liana G. and Barnes, Josephine and Bartzokis, George and Corbetta, Gabriele and DeCarli, Charles and deToledo-Morrell, Leyla and Pruessner, Jens C. and Frisoni, Giovanni B.}
}
kops.citation.iso690BOCCARDI, Marina, Martina BOCCHETTA, Liana G. APOSTOLOVA, Josephine BARNES, George BARTZOKIS, Gabriele CORBETTA, Charles DECARLI, Leyla DETOLEDO-MORRELL, Jens C. PRUESSNER, Giovanni B. FRISONI, 2015. Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance. In: Alzheimer's & Dementia. 2015, 11(2), pp. 126-138. ISSN 1552-5260. eISSN 1552-5279. Available under: doi: 10.1016/j.jalz.2014.02.009deu
kops.citation.iso690BOCCARDI, Marina, Martina BOCCHETTA, Liana G. APOSTOLOVA, Josephine BARNES, George BARTZOKIS, Gabriele CORBETTA, Charles DECARLI, Leyla DETOLEDO-MORRELL, Jens C. PRUESSNER, Giovanni B. FRISONI, 2015. Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance. In: Alzheimer's & Dementia. 2015, 11(2), pp. 126-138. ISSN 1552-5260. eISSN 1552-5279. Available under: doi: 10.1016/j.jalz.2014.02.009eng
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