@article{Kuhnt2012-04Intra-22431,
  year={2012},
  doi={10.1227/NEU.0b013e318237a807},
  title={Intraoperative Visualization of Fiber Tracking Based Reconstruction of Language Pathways in Glioma Surgery},
  number={4},
  volume={70},
  issn={0148-396X},
  journal={Neurosurgery},
  pages={911--920},
  author={Kuhnt, Daniela and Bauer, Miriam H. A. and Becker, Andreas and Merhof, Dorit and Zolal, Amir and Richter, Mirco and Grummich, Peter and Ganslandt, Oliver and Buchfelder, Michael and Nimsky, Christopher}
}

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    <dc:contributor>Ganslandt, Oliver</dc:contributor>
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    <dcterms:bibliographicCitation>Neurosurgery ; 70 (2012), 4. - S. 911-920</dcterms:bibliographicCitation>
    <dc:contributor>Buchfelder, Michael</dc:contributor>
    <dcterms:title>Intraoperative Visualization of Fiber Tracking Based Reconstruction of Language Pathways in Glioma Surgery</dcterms:title>
    <dc:creator>Zolal, Amir</dc:creator>
    <dc:contributor>Grummich, Peter</dc:contributor>
    <dcterms:issued>2012-04</dcterms:issued>
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    <dc:contributor>Kuhnt, Daniela</dc:contributor>
    <dc:creator>Grummich, Peter</dc:creator>
    <dc:creator>Bauer, Miriam H. A.</dc:creator>
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    <dc:contributor>Bauer, Miriam H. A.</dc:contributor>
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    <dc:contributor>Nimsky, Christopher</dc:contributor>
    <dc:creator>Richter, Mirco</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-13T10:55:40Z</dcterms:available>
    <dc:contributor>Richter, Mirco</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Merhof, Dorit</dc:creator>
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    <dc:creator>Becker, Andreas</dc:creator>
    <dc:contributor>Becker, Andreas</dc:contributor>
    <dcterms:abstract xml:lang="eng">BACKGROUND: For neuroepithelial tumors, the surgical goal is maximum resection with preservation of neurological function. This is contributed to by intraoperative magnetic resonance imaging (iMRI) combined with multimodal navigation.&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;OBJECTIVE: We evaluated the contribution of diffusion tensor imaging (DTI)-based fiber tracking of language pathways with 2 different algorithms (tensor deflection, connectivity analysis [CA]) integrated in the navigation on the surgical outcome.&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;METHODS: We evaluated 32 patients with neuroepithelial tumors who underwent surgery with DTI-based fiber tracking of language pathways integrated in neuronavigation. The tensor deflection algorithm was routinely used and its results intraoperatively displayed in all cases. The CA algorithm was furthermore evaluated in 23 cases. Volumetric assessment was performed in pre- and intraoperative MR images. To evaluate the benefit of fiber tractography, language deficits were evaluated pre- and postoperatively and compared with the volumetric analysis.&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;RESULTS: Final gross-total resection was performed in 40.6% of patients. Absolute tumor volume was reduced from 55.33 ± 63.77 cm3 to 20.61 ± 21.67 cm3 in first iMRI resection control, to finally 11.56 ± 21.92 cm3 (P &lt; .01). Fiber tracking of the 2 algorithms showed a deviation of the displayed 3D objects by &lt;5 mm. In long-term follow-up only 1 patient (3.1%) had a persistent language deficit.&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;CONCLUSION: Intraoperative visualization of language-related cortical areas and the connecting pathways with DTI-based fiber tracking can be successfully performed and integrated in the navigation system. In a setting of intraoperative high-field MRI this contributes to maximum tumor resection with low postoperative morbidity.</dcterms:abstract>
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    <dc:creator>Kuhnt, Daniela</dc:creator>
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    <dc:contributor>Merhof, Dorit</dc:contributor>
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    <dc:contributor>Zolal, Amir</dc:contributor>
    <dc:creator>Ganslandt, Oliver</dc:creator>
    <dc:creator>Buchfelder, Michael</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-13T10:55:40Z</dc:date>
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