Publikation:

The nascent polypeptide-associated complex (NAC) as regulatory hub on ribosomes

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2025

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https://doi.org/10.1515/hsz-2025-0114
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Deutsche Forschungsgemeinschaft (DFG): SPP 2453/P07 and 537004599
Deutsche Forschungsgemeinschaft (DFG): SFB969/A01

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Open Access-Veröffentlichung
Open Access Hybrid

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Biologie: Publikationen
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Published

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Biological Chemistry. De Gruyter. ISSN 1431-6730. eISSN 1437-4315. Verfügbar unter: doi: 10.1515/hsz-2025-0114

Zusammenfassung

The correct synthesis of new proteins is essential for maintaining a functional proteome and cell viability. This process is tightly regulated, with ribosomes and associated protein biogenesis factors ensuring proper protein production, modification, and targeting. In eukaryotes, the conserved nascent polypeptide-associated complex (NAC) plays a central role in coordinating early protein processing by regulating the ribosome access of multiple protein biogenesis factors. NAC recruits modifying enzymes to the ribosomal exit site to process the N-terminus of nascent proteins and directs secretory proteins into the SRP-mediated targeting pathway. In this review we will focus on these pathways, which are critical for proper protein production, and summarize recent advances in understanding the cotranslational functions and mechanisms of NAC in higher eukaryotes.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

ribosome-associated factors, cotranslational protein modification, methionine aminopeptidases (MetAPs), N-terminal acetyltransferases (NATs), cotranslational protein transport, signal recognition particle (SRP)

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ISO 690RABL, Laurenz, Elke DEUERLING, 2025. The nascent polypeptide-associated complex (NAC) as regulatory hub on ribosomes. In: Biological Chemistry. De Gruyter. ISSN 1431-6730. eISSN 1437-4315. Verfügbar unter: doi: 10.1515/hsz-2025-0114
BibTex
@article{Rabl2025-04-02nasce-72994,
  title={The nascent polypeptide-associated complex (NAC) as regulatory hub on ribosomes},
  year={2025},
  doi={10.1515/hsz-2025-0114},
  issn={1431-6730},
  journal={Biological Chemistry},
  author={Rabl, Laurenz and Deuerling, Elke}
}
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