Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1
Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1
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2011
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SP Mechanisms of Genome Haploidization -Regulatory Mechanisms of Meiosis in Vertebrate Oocytes-
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EMBO reports ; 12 (2011), 5. - S. 436-443. - ISSN 1469-221X. - eISSN 1469-3178
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Mature Xenopus oocytes are arrested in meiosis by the activity of XErp1/Emi2, an inhibitor of the ubiquitin-ligase anaphase-promoting complex/cyclosome (APC/C). On fertilization, XErp1 is degraded, resulting in APC/C activation and the consequent degradation of cell-cycle regulators and exit from meiosis. In this study, we show that a modest increase in the activity of the ubiquitin-conjugating enzyme UbcX overrides the meiotic arrest in an APC/C-dependent reaction. Intriguingly, XErp1 remains stable in these conditions. We found that UbcX causes the ubiquitylation of XErp1, followed by its dissociation from the APC/C. Our data support the idea that ubiquitylation regulates the APC/C-inhibitory activity of XErp1.
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570 Biowissenschaften, Biologie
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HÖRMANSEDER, Eva Beate, Thomas TISCHER, Simone HEUBES, Olaf STEMMANN, Thomas U. MAYER, 2011. Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1. In: EMBO reports. 12(5), pp. 436-443. ISSN 1469-221X. eISSN 1469-3178. Available under: doi: 10.1038/embor.2011.32BibTex
@article{Hormanseder2011-05Nonpr-13685, year={2011}, doi={10.1038/embor.2011.32}, title={Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1}, number={5}, volume={12}, issn={1469-221X}, journal={EMBO reports}, pages={436--443}, author={Hörmanseder, Eva Beate and Tischer, Thomas and Heubes, Simone and Stemmann, Olaf and Mayer, Thomas U.} }
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