Publikation: Attention deficits and depressive symptoms improve differentially after rehabilitation of post-COVID condition : a prospective cohort study
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Background
Depressive and cognitive symptoms like fatigue, loss of energy or sleep disorders characterise the post-COVID condition. Post-COVID psychosomatic rehabilitation should focus on both symptom groups. The current prospective cohort study addresses the change in these symptoms in the context of a psychosomatic rehabilitation.
Method
N = 80 patients with post-COVID symptoms underwent psychological testing on admission and discharge: PHQ-9 questionnaire for depression, TAP - test battery for the attention test with the sub-tests working memory, sustained attention, divided attention and alertness. Sample characteristics, including health-related and work-related parameters, the general symptom load and the course of symptoms during the five weeks of rehabilitation were evaluated.
Results
On admission, the PHQ-9 indicated the presence of depressive symptoms in post-COVID patients (PHQ-9 = 15.15 ± 5.11). Over the course of rehabilitation, the depressive symptoms decreased to a sub-clinical level (PHQ-9 = 8.80 ± 4.61), suggesting a strong effect of post-COVID inpatient rehabilitation (Cohen's d = 1.57). At the same time, post-COVID patients showed clinically relevant impairments in attention and working memory that persisted throughout the rehabilitation period despite multimodal post-COVID treatment.
Conclusion
Over the course of post-COVID rehabilitation, depressive symptoms appear to be significantly reduced. With regard to cognitive impairment, a comparable effect within the short period of 5 weeks is not evident. Our results suggest the need for specific treatment of persistent neuropsychological deficits following post-COVID rehabilitation.
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KUPFERSCHMITT, Alexa, Michael JÖBGES, Jennifer RANDERATH, Thilo HINTERBERGER, Thomas H. LOEW, Volker KÖLLNER, 2023. Attention deficits and depressive symptoms improve differentially after rehabilitation of post-COVID condition : a prospective cohort study. In: Journal of Psychosomatic Research. Elsevier BV. 2023, 175, pp. 111540. ISSN 0022-3999. Available under: doi: 10.1016/j.jpsychores.2023.111540BibTex
@article{Kupferschmitt2023-12Atten-68122, year={2023}, doi={10.1016/j.jpsychores.2023.111540}, title={Attention deficits and depressive symptoms improve differentially after rehabilitation of post-COVID condition : a prospective cohort study}, volume={175}, issn={0022-3999}, journal={Journal of Psychosomatic Research}, author={Kupferschmitt, Alexa and Jöbges, Michael and Randerath, Jennifer and Hinterberger, Thilo and Loew, Thomas H. and Köllner, Volker}, note={Article Number: 111540} }
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