Attention deficits and depressive symptoms improve differentially after rehabilitation of post-COVID condition : a prospective cohort study

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2023
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Kupferschmitt, Alexa
Hinterberger, Thilo
Loew, Thomas H.
Köllner, Volker
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Journal of Psychosomatic Research. Elsevier BV. 2023, 175, pp. 111540. ISSN 0022-3999. Available under: doi: 10.1016/j.jpsychores.2023.111540
Zusammenfassung

Background

Depressive and cognitive symptoms like fatigue, loss of energy or sleep disorders characterise the post-COVID condition. Post-COVID psychosomatic rehabilitation should focus on both symptom groups. The current prospective cohort study addresses the change in these symptoms in the context of a psychosomatic rehabilitation.

Method

N = 80 patients with post-COVID symptoms underwent psychological testing on admission and discharge: PHQ-9 questionnaire for depression, TAP - test battery for the attention test with the sub-tests working memory, sustained attention, divided attention and alertness. Sample characteristics, including health-related and work-related parameters, the general symptom load and the course of symptoms during the five weeks of rehabilitation were evaluated.

Results

On admission, the PHQ-9 indicated the presence of depressive symptoms in post-COVID patients (PHQ-9 = 15.15 ± 5.11). Over the course of rehabilitation, the depressive symptoms decreased to a sub-clinical level (PHQ-9 = 8.80 ± 4.61), suggesting a strong effect of post-COVID inpatient rehabilitation (Cohen's d = 1.57). At the same time, post-COVID patients showed clinically relevant impairments in attention and working memory that persisted throughout the rehabilitation period despite multimodal post-COVID treatment.

Conclusion

Over the course of post-COVID rehabilitation, depressive symptoms appear to be significantly reduced. With regard to cognitive impairment, a comparable effect within the short period of 5 weeks is not evident. Our results suggest the need for specific treatment of persistent neuropsychological deficits following post-COVID rehabilitation.

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150 Psychologie
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Clinical Psychology
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ISO 690KUPFERSCHMITT, Alexa, Michael JÖBGES, Jennifer RANDERATH, Thilo HINTERBERGER, Thomas H. LOEW, Volker KÖLLNER, 2023. Attention deficits and depressive symptoms improve differentially after rehabilitation of post-COVID condition : a prospective cohort study. In: Journal of Psychosomatic Research. Elsevier BV. 2023, 175, pp. 111540. ISSN 0022-3999. Available under: doi: 10.1016/j.jpsychores.2023.111540
BibTex
@article{Kupferschmitt2023-12Atten-68122,
  year={2023},
  doi={10.1016/j.jpsychores.2023.111540},
  title={Attention deficits and depressive symptoms improve differentially after rehabilitation of post-COVID condition : a prospective cohort study},
  volume={175},
  issn={0022-3999},
  journal={Journal of Psychosomatic Research},
  author={Kupferschmitt, Alexa and Jöbges, Michael and Randerath, Jennifer and Hinterberger, Thilo and Loew, Thomas H. and Köllner, Volker},
  note={Article Number: 111540}
}
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    <dcterms:abstract>Background

Depressive and cognitive symptoms like fatigue, loss of energy or sleep disorders characterise the post-COVID condition. Post-COVID psychosomatic rehabilitation should focus on both symptom groups. The current prospective cohort study addresses the change in these symptoms in the context of a psychosomatic rehabilitation.

Method

N = 80 patients with post-COVID symptoms underwent psychological testing on admission and discharge: PHQ-9 questionnaire for depression, TAP - test battery for the attention test with the sub-tests working memory, sustained attention, divided attention and alertness. Sample characteristics, including health-related and work-related parameters, the general symptom load and the course of symptoms during the five weeks of rehabilitation were evaluated.

Results

On admission, the PHQ-9 indicated the presence of depressive symptoms in post-COVID patients (PHQ-9 = 15.15 ± 5.11). Over the course of rehabilitation, the depressive symptoms decreased to a sub-clinical level (PHQ-9 = 8.80 ± 4.61), suggesting a strong effect of post-COVID inpatient rehabilitation (Cohen's d = 1.57). At the same time, post-COVID patients showed clinically relevant impairments in attention and working memory that persisted throughout the rehabilitation period despite multimodal post-COVID treatment.

Conclusion

Over the course of post-COVID rehabilitation, depressive symptoms appear to be significantly reduced. With regard to cognitive impairment, a comparable effect within the short period of 5 weeks is not evident. Our results suggest the need for specific treatment of persistent neuropsychological deficits following post-COVID rehabilitation.</dcterms:abstract>
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