Bridging lectin binding sites by multivalent carbohydrates

Wittmann, Valentin; Pieters, Roland J.

Bridging lectin binding sites by multivalent carbohydrates

Dateien

Wittmann_258532.pdfGröße: 3.01 MBDownloads: 1083

Datum

2013

Autor:innen

Wittmann, Valentin

Pieters, Roland J.

Publikationstyp

Zeitschriftenartikel

unikn.publication.listelement.citation.prefix.version.undefined

Chemical Society Reviews. 2013, 42(10), pp. 4492-4503. ISSN 0306-0012. eISSN 1460-4744. Available under: doi: 10.1039/C3CS60089K

Zusammenfassung

Carbohydrate–protein interactions are involved in a multitude of biological recognition processes. Since individual protein–carbohydrate interactions are usually weak, multivalency is often required to achieve biologically relevant binding affinities and selectivities. Among the possible mechanisms responsible for binding enhancement by multivalency, the simultaneous attachment of a multivalent ligand to several binding sites of a multivalent receptor (i.e. chelation) has been proven to have a strong impact. This article summarizes recent examples of chelating lectin ligands of different size. Covered lectins include the Shiga-like toxin, where the shortest distance between binding sites is ca. 9 Å, wheat germ agglutinin (WGA) (shortest distance between binding sites 13–14 Å), LecA from Pseudomonas aeruginosa (shortest distance 26 Å), cholera toxin and heat-labile enterotoxin (shortest distance 31 Å), anti-HIV antibody 2G12 (shortest distance 31 Å), concanavalin A (ConA) (shortest distance 72 Å), RCA₁₂₀ (shortest distance 100 Å), and Erythrina cristagalli (ECL) (shortest distance 100 Å). While chelating binding of the discussed ligands is likely, experimental proof, for example by X-ray crystallography, is limited to only a few cases.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

WITTMANN, Valentin, Roland J. PIETERS, 2013. Bridging lectin binding sites by multivalent carbohydrates. In: Chemical Society Reviews. 2013, 42(10), pp. 4492-4503. ISSN 0306-0012. eISSN 1460-4744. Available under: doi: 10.1039/C3CS60089K

BibTex

@article{Wittmann2013-05-21Bridg-25853,
  year={2013},
  doi={10.1039/C3CS60089K},
  title={Bridging lectin binding sites by multivalent carbohydrates},
  number={10},
  volume={42},
  issn={0306-0012},
  journal={Chemical Society Reviews},
  pages={4492--4503},
  author={Wittmann, Valentin and Pieters, Roland J.}
}

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