Identification and developmental expression of two Tbx1/10 -related genes in the agnathan Lethenteron japonicum

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Tiecke07_DGE_LjTbx1_10.pdf
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2007
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Tiecke, Eva
Matsuura, Manami
Kokubo, Nobuhiro
Kusakabe, Rie
Kuratani, Shigeru
Tanaka, Mikiko
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Development genes and evolution. 2007, 217(10), pp. 691-697. ISSN 0949-944X. eISSN 1432-041X
Zusammenfassung

We have identified two Tbx1/10-related genes, LjTbx1/10A and LjTbx1/10B, from the Japanese river lamprey Lethenteron japonicum. We used in situ hybridization to characterize their expression pattern during embryonic development. LjTbx1/10A and LjTbx1/10B shared common expression in the pharyngeal arches and otic vesicle, although their levels and timing of expression differed markedly. LjTbx1/10A was highly expressed in the mesodermal core of pharyngeal arches and the adjacent endoderm throughout pharyngeal arch development, whereas LjTbx1/10B expression was only transiently upregulated in forming pharyngeal pouches. LjTbx1/10A transcripts first appeared at stage 25 in otic vesicles, whereas LjTbx1/10B transcripts could already be detected in the developing otic placode at stage 20. These results suggest that lamprey LjTbx1/10A and LjTbx1/10B may play distinct roles in the patterning and development of the pharyngeal apparatus. It appears that lamprey Tbx1/10 genes have undergone subfunctionalization independent from gnathostomes, with regard to both regulation and function.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie
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T-box, Tbx1, Tbx10, Lamprey
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undefined / . - undefined, undefined
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ISO 690TIECKE, Eva, Manami MATSUURA, Nobuhiro KOKUBO, Shigehiro KURAKU, Rie KUSAKABE, Shigeru KURATANI, Mikiko TANAKA, 2007. Identification and developmental expression of two Tbx1/10 -related genes in the agnathan Lethenteron japonicum. In: Development genes and evolution. 2007, 217(10), pp. 691-697. ISSN 0949-944X. eISSN 1432-041X
BibTex
@article{Tiecke2007Ident-7623,
  year={2007},
  title={Identification and developmental expression of two Tbx1/10  -related genes in the agnathan Lethenteron japonicum},
  number={10},
  volume={217},
  issn={0949-944X},
  journal={Development genes and evolution},
  pages={691--697},
  author={Tiecke, Eva and Matsuura, Manami and Kokubo, Nobuhiro and Kuraku, Shigehiro and Kusakabe, Rie and Kuratani, Shigeru and Tanaka, Mikiko}
}
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