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Interaction of membrane-spanning proteins with peripheral and lipid-anchored membrane proteins : perspectives from protein-lipid interactions (Review)

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Interaction_of_membrane_spanning_proteins_with_peripheral_and_lipid_anchored_membrane_proteins.pdf
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Datum

2002

Autor:innen

Marsh, Derek
Horváth, László I.
Swamy, Musti. J.
Mantripragada, Sankaram

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-55676
DOI (zitierfähiger Link)
https://doi.org/10.1080/09687680210162419
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Attribution-NonCommercial-NoDerivs 2.0 Generic

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Open Access-Veröffentlichung
Open Access Green

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Biologie: Publikationen
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Published

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Molecular Membrane Biology. 2002, 19(4), pp. 247-255. ISSN 0968-7688. eISSN 1464-5203. Available under: doi: 10.1080/09687680210162419

Zusammenfassung

Studies of lipid-protein interactions in double-reconstituted systems involving both integral and peripheral or lipid-anchored proteins are reviewed. Membranes of dimyristoyl phosphatidylglycerol containing either myelin proteolipid protein or cytochrome c oxidase were studied. The partner peripheral proteins bound to these membranes were myelin basic protein or cytochrome c, respectively. In addition, the interactions between the myelin proteolipid protein and avidin that was membraneanchored by binding to N-biotinyl phosphatidylethanolamine were studied in dimyristoyl phosphatidylcholine membranes. Steric exclusion plays a significant role when sizes of the peripheral protein and transmembrane domain of the integral protein are comparable. Even so, the effects on avidin-linked lipids are different from those induced by myelin basic protein on freely diffusible lipids, both interacting with the myelin proteolipid protein. Both the former and the cytochrome c/cytochrome oxidase couple evidence a propagation of lipid perturbation out from the intramembrane protein interface that could be a basis for formation of microdomains.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Lipid-protein interactions, spin labels, electron spin resonance, myelin proteins, cytochrome oxidase

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ISO 690MARSH, Derek, László I. HORVÁTH, Musti. J. SWAMY, Sankaram MANTRIPRAGADA, Jörg KLEINSCHMIDT, 2002. Interaction of membrane-spanning proteins with peripheral and lipid-anchored membrane proteins : perspectives from protein-lipid interactions (Review). In: Molecular Membrane Biology. 2002, 19(4), pp. 247-255. ISSN 0968-7688. eISSN 1464-5203. Available under: doi: 10.1080/09687680210162419
BibTex
@article{Marsh2002Inter-7268,
  year={2002},
  doi={10.1080/09687680210162419},
  title={Interaction of membrane-spanning proteins with peripheral and lipid-anchored membrane proteins : perspectives from protein-lipid interactions (Review)},
  number={4},
  volume={19},
  issn={0968-7688},
  journal={Molecular Membrane Biology},
  pages={247--255},
  author={Marsh, Derek and Horváth, László I. and Swamy, Musti. J. and Mantripragada, Sankaram and Kleinschmidt, Jörg}
}
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