Interaction of membrane-spanning proteins with peripheral and lipid-anchored membrane proteins : perspectives from protein-lipid interactions (Review)

Marsh, Derek; Horváth, László I.; Swamy, Musti. J.; Mantripragada, Sankaram; Kleinschmidt, Jörg

Interaction of membrane-spanning proteins with peripheral and lipid-anchored membrane proteins : perspectives from protein-lipid interactions (Review)

Dateien

Interaction_of_membrane_spanning_proteins_with_peripheral_and_lipid_anchored_membrane_proteins.pdfGröße: 865.56 KBDownloads: 453

Datum

2002

Autor:innen

Marsh, Derek

Horváth, László I.

Swamy, Musti. J.

Mantripragada, Sankaram

Kleinschmidt, Jörg

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Molecular Membrane Biology. 2002, 19(4), pp. 247-255. ISSN 0968-7688. eISSN 1464-5203. Available under: doi: 10.1080/09687680210162419

Zusammenfassung

Studies of lipid-protein interactions in double-reconstituted systems involving both integral and peripheral or lipid-anchored proteins are reviewed. Membranes of dimyristoyl phosphatidylglycerol containing either myelin proteolipid protein or cytochrome c oxidase were studied. The partner peripheral proteins bound to these membranes were myelin basic protein or cytochrome c, respectively. In addition, the interactions between the myelin proteolipid protein and avidin that was membraneanchored by binding to N-biotinyl phosphatidylethanolamine were studied in dimyristoyl phosphatidylcholine membranes. Steric exclusion plays a significant role when sizes of the peripheral protein and transmembrane domain of the integral protein are comparable. Even so, the effects on avidin-linked lipids are different from those induced by myelin basic protein on freely diffusible lipids, both interacting with the myelin proteolipid protein. Both the former and the cytochrome c/cytochrome oxidase couple evidence a propagation of lipid perturbation out from the intramembrane protein interface that could be a basis for formation of microdomains.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Lipid-protein interactions, spin labels, electron spin resonance, myelin proteins, cytochrome oxidase

Zitieren

ISO 690

MARSH, Derek, László I. HORVÁTH, Musti. J. SWAMY, Sankaram MANTRIPRAGADA, Jörg KLEINSCHMIDT, 2002. Interaction of membrane-spanning proteins with peripheral and lipid-anchored membrane proteins : perspectives from protein-lipid interactions (Review). In: Molecular Membrane Biology. 2002, 19(4), pp. 247-255. ISSN 0968-7688. eISSN 1464-5203. Available under: doi: 10.1080/09687680210162419

BibTex

@article{Marsh2002Inter-7268,
  year={2002},
  doi={10.1080/09687680210162419},
  title={Interaction of membrane-spanning proteins with peripheral and lipid-anchored membrane proteins : perspectives from protein-lipid interactions (Review)},
  number={4},
  volume={19},
  issn={0968-7688},
  journal={Molecular Membrane Biology},
  pages={247--255},
  author={Marsh, Derek and Horváth, László I. and Swamy, Musti. J. and Mantripragada, Sankaram and Kleinschmidt, Jörg}
}

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