Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa : Between Immune Homeostasis and Immune Escape

Kurzanzeige
dc.contributor.authorAhmed, Asma
dc.contributor.authorSchmidt, Christian
dc.contributor.authorBrunner, Thomas
dc.date.accessioned2019-07-18T11:38:18Z
dc.date.available2019-07-18T11:38:18Z
dc.date.issued2019-06-25eng
dc.description.abstractGlucocorticoids (GCs) are steroid hormones predominantly produced in the adrenal glands in response to physiological cues and stress. Adrenal GCs mediate potent anti-inflammatory and immunosuppressive functions. Accumulating evidence in the past two decades has demonstrated other extra-adrenal organs and tissues capable of synthesizing GCs. This review discusses the role and regulation of GC synthesis in the intestinal epithelium in the regulation of normal immune homeostasis, inflammatory diseases of the intestinal mucosa, and the development of intestinal tumors.eng
dc.description.versionpublishedde
dc.identifier.doi10.3389/fimmu.2019.01438eng
dc.identifier.ppn1669586383
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/46452
dc.language.isoengeng
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectglucocorticoids, intestinal mucosa, intestinal immune homeostasis, inflammatory bowel disease, colorectal cancer, liver receptor homolog-1, tumor necrosis factoreng
dc.subject.ddc570eng
dc.titleExtra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa : Between Immune Homeostasis and Immune Escapeeng
dc.typeJOURNAL_ARTICLEde
dspace.entity.typePublication
kops.citation.bibtex
@article{Ahmed2019-06-25Extra-46452,
  year={2019},
  doi={10.3389/fimmu.2019.01438},
  title={Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa : Between Immune Homeostasis and Immune Escape},
  volume={10},
  journal={Frontiers in Immunology},
  author={Ahmed, Asma and Schmidt, Christian and Brunner, Thomas},
  note={Article Number: 1438}
}
kops.citation.iso690AHMED, Asma, Christian SCHMIDT, Thomas BRUNNER, 2019. Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa : Between Immune Homeostasis and Immune Escape. In: Frontiers in Immunology. 2019, 10, 1438. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2019.01438deu
kops.citation.iso690AHMED, Asma, Christian SCHMIDT, Thomas BRUNNER, 2019. Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa : Between Immune Homeostasis and Immune Escape. In: Frontiers in Immunology. 2019, 10, 1438. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2019.01438eng
kops.citation.rdf
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/46452">
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-07-18T11:38:18Z</dcterms:available>
    <dcterms:issued>2019-06-25</dcterms:issued>
    <dc:creator>Ahmed, Asma</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Brunner, Thomas</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/46452"/>
    <dc:creator>Brunner, Thomas</dc:creator>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <dc:contributor>Schmidt, Christian</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dcterms:abstract xml:lang="eng">Glucocorticoids (GCs) are steroid hormones predominantly produced in the adrenal glands in response to physiological cues and stress. Adrenal GCs mediate potent anti-inflammatory and immunosuppressive functions. Accumulating evidence in the past two decades has demonstrated other extra-adrenal organs and tissues capable of synthesizing GCs. This review discusses the role and regulation of GC synthesis in the intestinal epithelium in the regulation of normal immune homeostasis, inflammatory diseases of the intestinal mucosa, and the development of intestinal tumors.</dcterms:abstract>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/46452/1/Ahmed_2-ljxg5sol5th42.pdf"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/46452/1/Ahmed_2-ljxg5sol5th42.pdf"/>
    <dcterms:title>Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa : Between Immune Homeostasis and Immune Escape</dcterms:title>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-07-18T11:38:18Z</dc:date>
    <dc:creator>Schmidt, Christian</dc:creator>
    <dc:language>eng</dc:language>
    <dc:contributor>Ahmed, Asma</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
  </rdf:Description>
</rdf:RDF>
kops.description.openAccessopenaccessgoldeng
kops.flag.isPeerReviewedtrueeng
kops.flag.knbibliographytrue
kops.identifier.nbnurn:nbn:de:bsz:352-2-ljxg5sol5th42
kops.sourcefieldFrontiers in Immunology. 2019, <b>10</b>, 1438. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2019.01438deu
kops.sourcefield.plainFrontiers in Immunology. 2019, 10, 1438. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2019.01438deu
kops.sourcefield.plainFrontiers in Immunology. 2019, 10, 1438. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2019.01438eng
relation.isAuthorOfPublicatione042aee0-afca-4f61-aa50-2481f397926c
relation.isAuthorOfPublication8116b665-5780-4dd3-9d67-e9836d44e537
relation.isAuthorOfPublicationf61b843f-0378-4683-b89b-70ad6aec10ea
relation.isAuthorOfPublication.latestForDiscoverye042aee0-afca-4f61-aa50-2481f397926c
source.bibliographicInfo.articleNumber1438eng
source.bibliographicInfo.volume10eng
source.identifier.eissn1664-3224eng
source.periodicalTitleFrontiers in Immunologyeng

Dateien

Originalbündel

Gerade angezeigt 1 - 1 von 1
Vorschaubild nicht verfügbar
Name:
Ahmed_2-ljxg5sol5th42.pdf
Größe:
3.76 MB
Format:
Adobe Portable Document Format
Beschreibung:
Ahmed_2-ljxg5sol5th42.pdf
Ahmed_2-ljxg5sol5th42.pdfGröße: 3.76 MBDownloads: 314

Sammlungen

Biologie: Publikationen