Nitroimidazoles Part 7 : Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives

Al-Masoudi, Najim A.; Pfleiderer, Wolfgang; Pannecouque, Christophe

Nitroimidazoles Part 7 : Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives

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Date

2012

Authors

Al-Masoudi, Najim A.

Pfleiderer, Wolfgang

Pannecouque, Christophe

Publication type

Journal article

Published in

Zeitschrift für Naturforschung B ; 67 (2012), 8. - ISSN 1865-7117

Abstract

Reverse transcriptase enzyme (RT) is an attractive target for the development of new drugs useful in AIDS therapy and HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs), and offers the possibility of generating structures of increased potency. On this basis, a series of 4-oxo-3-phenyl-2-(phenylimino)thiazolidin-5-ylidene, 3-hydroxypropyl, 3-azidopropyl, and 3-aminopropyl derivatives of 1-benzyl-2-ethyl-4-nitroimidazoles 6–8, as well as the substituted 1,2,3-triazolo analogs 12–14, the diazepam 15 and carboxamide derivatives 16 and 17 were synthesized. All compounds have been evaluated for their anti-HIV activity.

Subject (DDC)

540 Chemistry

Keywords

Anti-HIV activity,Nitroimidazoles,NNRTIs,Piperazine Derivatives

Cite This

ISO 690

AL-MASOUDI, Najim A., Wolfgang PFLEIDERER, Christophe PANNECOUQUE, 2012. Nitroimidazoles Part 7 : Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives. In: Zeitschrift für Naturforschung B. 67(8). ISSN 1865-7117. Available under: doi: 10.5560/ZNB.2012-0122

BibTex

@article{AlMasoudi2012Nitro-22647,
  year={2012},
  doi={10.5560/ZNB.2012-0122},
  title={Nitroimidazoles Part 7 : Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives},
  number={8},
  volume={67},
  issn={1865-7117},
  journal={Zeitschrift für Naturforschung B},
  author={Al-Masoudi, Najim A. and Pfleiderer, Wolfgang and Pannecouque, Christophe}
}

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