Synthesis of the core structure of the lipoteichoic acid of streptococcus pneumoniae

Lade...
Vorschaubild
Dateien
Schmidt_etal.pdf
Schmidt_etal.pdfGröße: 1.04 MBDownloads: 804
Datum
2010
Autor:innen
Pedersen, Christian Marcus
Figueroa-Perez, Ignacio
Boruwa, Joshodeep
Lindner, Buko
Ulmer, Artur J.
Zähringer, Ulrich
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Chemistry - A European Journal. 2010, 16(42), pp. 12627-12641. ISSN 0947-6539. eISSN 1521-3765. Available under: doi: 10.1002/chem.201001204
Zusammenfassung

Streptococcus pneumoniae LTA is a highly complex glycophospholipid that consists of nine carbohydrate residues: three glucose, two galactosamine and two 2-acetamino-4-amino-2,4,6-trideoxygalactose (AATDgal) residues that are each differently linked, one ribitol and one diacylated glycerol (DAG) residue. Suitable building blocks for the glucose and the AATDgal residues were designed and their synthesis is described in this paper. These building blocks permitted the successful synthesis of the core structure GlcBeta(1-3)AATDgalBeta(1-3)GlcAlpha(1-O)DAG in a suitably protected form for further chain extension (lb, le) and as unprotected glycolipid (la) that was employed in biological studies. These studies revealed that la as well as 1 lead to interleukin-8 release, however not via TLR2 or TLR4 as receptor.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
540 Chemie
Schlagwörter
carbohydrates, glycolipids, glycosidation, receptor recognition, total synthesis
Konferenz
Rezension
undefined / . - undefined, undefined
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Datensätze
Zitieren
ISO 690PEDERSEN, Christian Marcus, Ignacio FIGUEROA-PEREZ, Joshodeep BORUWA, Buko LINDNER, Artur J. ULMER, Ulrich ZÄHRINGER, Richard R. SCHMIDT, 2010. Synthesis of the core structure of the lipoteichoic acid of streptococcus pneumoniae. In: Chemistry - A European Journal. 2010, 16(42), pp. 12627-12641. ISSN 0947-6539. eISSN 1521-3765. Available under: doi: 10.1002/chem.201001204
BibTex
@article{Pedersen2010-11-08Synth-384,
  year={2010},
  doi={10.1002/chem.201001204},
  title={Synthesis of the core structure of the lipoteichoic acid of streptococcus pneumoniae},
  number={42},
  volume={16},
  issn={0947-6539},
  journal={Chemistry - A European Journal},
  pages={12627--12641},
  author={Pedersen, Christian Marcus and Figueroa-Perez, Ignacio and Boruwa, Joshodeep and Lindner, Buko and Ulmer, Artur J. and Zähringer, Ulrich and Schmidt, Richard R.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/384">
    <dc:format>application/pdf</dc:format>
    <dc:contributor>Zähringer, Ulrich</dc:contributor>
    <dc:creator>Lindner, Buko</dc:creator>
    <dc:language>eng</dc:language>
    <dcterms:title>Synthesis of the core structure of the lipoteichoic acid of streptococcus pneumoniae</dcterms:title>
    <dc:creator>Pedersen, Christian Marcus</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: Chemistry : a European journal 16 (2010), 42, pp. 12627–12641</dcterms:bibliographicCitation>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/384/1/Schmidt_etal.pdf"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-07-04T12:04:27Z</dcterms:available>
    <dcterms:issued>2010-11-08</dcterms:issued>
    <dc:creator>Zähringer, Ulrich</dc:creator>
    <dc:creator>Figueroa-Perez, Ignacio</dc:creator>
    <dc:creator>Boruwa, Joshodeep</dc:creator>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/384"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Figueroa-Perez, Ignacio</dc:contributor>
    <dc:creator>Schmidt, Richard R.</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/384/1/Schmidt_etal.pdf"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-07-04T12:04:27Z</dc:date>
    <dcterms:abstract xml:lang="eng">Streptococcus pneumoniae LTA is a highly complex glycophospholipid that consists of nine carbohydrate residues: three glucose, two galactosamine and two 2-acetamino-4-amino-2,4,6-trideoxygalactose (AATDgal) residues that are each differently linked, one ribitol and one diacylated glycerol (DAG) residue. Suitable building blocks for the glucose and the AATDgal residues were designed and their synthesis is described in this paper. These building blocks permitted the successful synthesis of the core structure GlcBeta(1-3)AATDgalBeta(1-3)GlcAlpha(1-O)DAG in a suitably protected form for further chain extension (lb, le) and as unprotected glycolipid (la) that was employed in biological studies. These studies revealed that la as well as 1 lead to interleukin-8 release, however not via TLR2 or TLR4 as receptor.</dcterms:abstract>
    <dc:contributor>Lindner, Buko</dc:contributor>
    <dc:contributor>Boruwa, Joshodeep</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Ulmer, Artur J.</dc:creator>
    <dc:contributor>Schmidt, Richard R.</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Ulmer, Artur J.</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:contributor>Pedersen, Christian Marcus</dc:contributor>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Begutachtet
Diese Publikation teilen