Publikation: Regulation of Cell Division
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2017
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PELEGRI, Francisco, ed., Michael DANILCHIK, ed., Ann SUTHERLAND, ed.. Vertebrate Development : Maternal to Zygotic Control. Cham: Springer International Publishing, 2017, pp. 83-116. Advances in Experimental Medicine and Biology. 953. ISBN 978-3-319-46093-2. Available under: doi: 10.1007/978-3-319-46095-6_3
Zusammenfassung
The challenging task of mitotic cell divisions is to generate two genetically identical daughter cells from a single precursor cell. To accomplish this task, a complex regulatory network evolved, which ensures that all events critical for the duplication of cellular contents and their subsequent segregation occur in the correct order, at specific intervals and with the highest possible fidelity. Transitions between cell cycle stages are triggered by changes in the phosphorylation state and levels of components of the cell cycle machinery. Entry into S-phase and M-phase are mediated by cyclin-dependent kinases (Cdks), serine-threonine kinases that require a regulatory cyclin subunit for their activity. Resetting the system to the interphase state is mediated by protein phosphatases (PPs) that counteract Cdks by dephosphorylating their substrates. To avoid futile cycles of phosphorylation and dephosphorylation, Cdks and PPs must be regulated in a manner such that their activities are mutually exclusive.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Cell cycle regulation, Cyclin-dependent kinase 1 (Cdk1), Type 2A protein phosphatase (PP2A), Type 1 protein phosphatase (PP1), Anaphase-promoting complex/cyclosome (APC/C)
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HEIM, Andreas, Beata RYMARCZYK, Saurav MALHOTRA, Thomas U. MAYER, 2017. Regulation of Cell Division. In: PELEGRI, Francisco, ed., Michael DANILCHIK, ed., Ann SUTHERLAND, ed.. Vertebrate Development : Maternal to Zygotic Control. Cham: Springer International Publishing, 2017, pp. 83-116. Advances in Experimental Medicine and Biology. 953. ISBN 978-3-319-46093-2. Available under: doi: 10.1007/978-3-319-46095-6_3BibTex
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year={2017},
doi={10.1007/978-3-319-46095-6_3},
title={Regulation of Cell Division},
number={953},
isbn={978-3-319-46093-2},
publisher={Springer International Publishing},
address={Cham},
series={Advances in Experimental Medicine and Biology},
booktitle={Vertebrate Development : Maternal to Zygotic Control},
pages={83--116},
editor={Pelegri, Francisco and Danilchik, Michael and Sutherland, Ann},
author={Heim, Andreas and Rymarczyk, Beata and Malhotra, Saurav and Mayer, Thomas U.}
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