Regulation of Cell Division

Heim, Andreas; Rymarczyk, Beata; Malhotra, Saurav; Mayer, Thomas U.

Regulation of Cell Division

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2017

Publikationstyp

Beitrag zu einem Sammelband

Publikationsstatus

Published

Erschienen in

PELEGRI, Francisco, ed., Michael DANILCHIK, ed., Ann SUTHERLAND, ed.. Vertebrate Development : Maternal to Zygotic Control. Cham: Springer International Publishing, 2017, pp. 83-116. Advances in Experimental Medicine and Biology. 953. ISBN 978-3-319-46093-2. Available under: doi: 10.1007/978-3-319-46095-6_3

Zusammenfassung

The challenging task of mitotic cell divisions is to generate two genetically identical daughter cells from a single precursor cell. To accomplish this task, a complex regulatory network evolved, which ensures that all events critical for the duplication of cellular contents and their subsequent segregation occur in the correct order, at specific intervals and with the highest possible fidelity. Transitions between cell cycle stages are triggered by changes in the phosphorylation state and levels of components of the cell cycle machinery. Entry into S-phase and M-phase are mediated by cyclin-dependent kinases (Cdks), serine-threonine kinases that require a regulatory cyclin subunit for their activity. Resetting the system to the interphase state is mediated by protein phosphatases (PPs) that counteract Cdks by dephosphorylating their substrates. To avoid futile cycles of phosphorylation and dephosphorylation, Cdks and PPs must be regulated in a manner such that their activities are mutually exclusive.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Cell cycle regulation, Cyclin-dependent kinase 1 (Cdk1), Type 2A protein phosphatase (PP2A), Type 1 protein phosphatase (PP1), Anaphase-promoting complex/cyclosome (APC/C)

Zitieren

ISO 690

HEIM, Andreas, Beata RYMARCZYK, Saurav MALHOTRA, Thomas U. MAYER, 2017. Regulation of Cell Division. In: PELEGRI, Francisco, ed., Michael DANILCHIK, ed., Ann SUTHERLAND, ed.. Vertebrate Development : Maternal to Zygotic Control. Cham: Springer International Publishing, 2017, pp. 83-116. Advances in Experimental Medicine and Biology. 953. ISBN 978-3-319-46093-2. Available under: doi: 10.1007/978-3-319-46095-6_3

BibTex

@incollection{Heim2017Regul-37730,
  year={2017},
  doi={10.1007/978-3-319-46095-6_3},
  title={Regulation of Cell Division},
  number={953},
  isbn={978-3-319-46093-2},
  publisher={Springer International Publishing},
  address={Cham},
  series={Advances in Experimental Medicine and Biology},
  booktitle={Vertebrate Development : Maternal to Zygotic Control},
  pages={83--116},
  editor={Pelegri, Francisco and Danilchik, Michael and Sutherland, Ann},
  author={Heim, Andreas and Rymarczyk, Beata and Malhotra, Saurav and Mayer, Thomas U.}
}

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Universitätsbibliographie

Ja