Impact of childhood trauma on positive and negative symptom remission in first episode psychosis

Pruessner, Marita; King, Suzanne; Veru, Franz; Schalinski, Inga; Vracotas, Nadia; Abadi, Sherezad; Jordan, Gerald; Lepage, Martin; Iyer, Srividya; Malla, Ashok K.

Impact of childhood trauma on positive and negative symptom remission in first episode psychosis

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2021

Autor:innen

Pruessner, Marita

King, Suzanne

Veru, Franz

Schalinski, Inga

Vracotas, Nadia

Abadi, Sherezad

Jordan, Gerald

Lepage, Martin

Iyer, Srividya

Malla, Ashok K.

et al.

DOI (zitierfähiger Link)

https://doi.org/10.1016/j.schres.2021.02.023

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Schizophrenia Research. Elsevier. 2021, 231, pp. 82-89. ISSN 0920-9964. eISSN 1573-2509. Available under: doi: 10.1016/j.schres.2021.02.023

Zusammenfassung

Objective
Early life adversity is suspected to play an important role for onset and course of psychosis, but its relationship with longer-term clinical outcome is not entirely clear. In this longitudinal study, we investigated the impact of childhood trauma (CT) on positive and negative symptom remission in first episode psychosis (FEP) patients over two years.

Methods
A total of 210 FEP patients were assessed with the Childhood Trauma Questionnaire. Patients reporting moderate to severe trauma (CT; N = 114; 54.3%) were compared to those without trauma (N-CT; N = 96; 45.7%). Positive (PSR) and negative symptom remission (NSR) were determined monthly over 24 months following established criteria using the Scale for Assessment of Positive Symptoms and the Scale for Assessment of Negative Symptoms. Global Functioning was evaluated at baseline and 24 months of follow-up.

Results
Compared to N-CT patients, CT patients had achieved significantly lower rates of PSR at 12 months and significantly lower rates of NSR at 24 months. A dose-response relationship was observed between the number of trauma categories fulfilled and the number of patients not achieving PSR and NSR at these time points. Higher trauma scores were significantly associated with poor functioning and higher positive and negative symptom severity at 24 months, but not at baseline and 12 months of follow-up.

Conclusion
Differential effects of CT on clinical outcome may not be apparent at psychosis onset, but only become evident through poor symptomatic remission and general functioning over time. Targeted diagnostic and therapeutic efforts after illness onset might limit these detrimental consequences.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

Schizophrenia, First episode psychosis, Early life adversity, Childhood trauma, Symptom remission

Zitieren

ISO 690

PRUESSNER, Marita, Suzanne KING, Franz VERU, Inga SCHALINSKI, Nadia VRACOTAS, Sherezad ABADI, Gerald JORDAN, Martin LEPAGE, Srividya IYER, Ashok K. MALLA, 2021. Impact of childhood trauma on positive and negative symptom remission in first episode psychosis. In: Schizophrenia Research. Elsevier. 2021, 231, pp. 82-89. ISSN 0920-9964. eISSN 1573-2509. Available under: doi: 10.1016/j.schres.2021.02.023

BibTex

@article{Pruessner2021-03-31Impac-53343,
  year={2021},
  doi={10.1016/j.schres.2021.02.023},
  title={Impact of childhood trauma on positive and negative symptom remission in first episode psychosis},
  volume={231},
  issn={0920-9964},
  journal={Schizophrenia Research},
  pages={82--89},
  author={Pruessner, Marita and King, Suzanne and Veru, Franz and Schalinski, Inga and Vracotas, Nadia and Abadi, Sherezad and Jordan, Gerald and Lepage, Martin and Iyer, Srividya and Malla, Ashok K.}
}

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