Allostatic load associations to acute, 3-year and 6-year prospective depressive symptoms in healthy older adults

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2011
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Juster, Robert-Paul
Marin, Marie-France
Sindi, Shireen
Nair, N.P. Vasavan
Ng, Ying Kin
Lupien, Sonia J.
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Physiology & Behavior. 2011, 104(2), pp. 360-364. ISSN 0031-9384. eISSN 1873-507X. Available under: doi: 10.1016/j.physbeh.2011.02.027
Zusammenfassung

Allostatic load represents the strain that chronic stress exerts on interconnected biological systems. Associated algorithms are related to numerous deleterious physical outcomes in older populations, and yet few studies have assessed associations to mental health outcomes like geriatric depression. Using data from the Douglas Hospital Longitudinal Study of Normal and Pathological Aging, we assessed whether using an allostatic load index derived from seven biomarkers could detect self-rated depressive symptoms in 58 healthy older adults followed longitudinally over a 6-year period. Our results revealed that increased allostatic load was associated with increased depressive symptoms on the same year of assessment. After 3 years, AL was prospectively associated with depressive symptoms, but entering age and sex as covariates attenuated this effect to a trend. Only age emerged as a significant predictor of depressive symptoms over 6 years. These findings suggest that increased AL in older age is only associated with depressive symptomatology acutely. Over longer periods of time, however, the physical and psychological sequelae of advanced age may contribute to increased depressive symptoms via pathways otherwise undetectable using allostatic load indices of sub-clinical physiological dysregulations.

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Fachgebiet (DDC)
150 Psychologie
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Allostatic load; Geriatric depression; Chronic stress; Cortisol; Pathophysiology
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ISO 690JUSTER, Robert-Paul, Marie-France MARIN, Shireen SINDI, N.P. Vasavan NAIR, Ying Kin NG, Jens C. PRUESSNER, Sonia J. LUPIEN, 2011. Allostatic load associations to acute, 3-year and 6-year prospective depressive symptoms in healthy older adults. In: Physiology & Behavior. 2011, 104(2), pp. 360-364. ISSN 0031-9384. eISSN 1873-507X. Available under: doi: 10.1016/j.physbeh.2011.02.027
BibTex
@article{Juster2011-08Allos-38466,
  year={2011},
  doi={10.1016/j.physbeh.2011.02.027},
  title={Allostatic load associations to acute, 3-year and 6-year prospective depressive symptoms in healthy older adults},
  number={2},
  volume={104},
  issn={0031-9384},
  journal={Physiology & Behavior},
  pages={360--364},
  author={Juster, Robert-Paul and Marin, Marie-France and Sindi, Shireen and Nair, N.P. Vasavan and Ng, Ying Kin and Pruessner, Jens C. and Lupien, Sonia J.}
}
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    <dcterms:abstract xml:lang="eng">Allostatic load represents the strain that chronic stress exerts on interconnected biological systems. Associated algorithms are related to numerous deleterious physical outcomes in older populations, and yet few studies have assessed associations to mental health outcomes like geriatric depression. Using data from the Douglas Hospital Longitudinal Study of Normal and Pathological Aging, we assessed whether using an allostatic load index derived from seven biomarkers could detect self-rated depressive symptoms in 58 healthy older adults followed longitudinally over a 6-year period. Our results revealed that increased allostatic load was associated with increased depressive symptoms on the same year of assessment. After 3 years, AL was prospectively associated with depressive symptoms, but entering age and sex as covariates attenuated this effect to a trend. Only age emerged as a significant predictor of depressive symptoms over 6 years. These findings suggest that increased AL in older age is only associated with depressive symptomatology acutely. Over longer periods of time, however, the physical and psychological sequelae of advanced age may contribute to increased depressive symptoms via pathways otherwise undetectable using allostatic load indices of sub-clinical physiological dysregulations.</dcterms:abstract>
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