Expression of an L1-Related Cell Adhesion Molecule on Developing CNS Fiber Tracts in Zebrafish and Its Functional Contribution to Axon Fasciculation

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1997
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Weiland, Ulrich M.
Ott, Heiko
Bastmeyer, Martin
Schaden, Herbert
Giordano, Suzanne
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Molecular and Cellular Neuroscience. 1997, 9(1), pp. 77-89. ISSN 1044-7431. Available under: doi: 10.1006/mcne.1997.0603
Zusammenfassung

E587 antigen, an L1-related cell adhesion molecule, is expressed by growing axons and has previously been shown to enhance axon growth and to mediate fasciculation of axons from newborn retinal ganglion cells in goldfish. In zebrafish, the monoclonal antibody E17 against E587 antigen stains all axons in the primary tracts and commissures from 17 h postfertilization (pf) onward and axons which are added subsequently to this scaffold. Moreover, Fab fragments of an E587 antiserum (E587 Fabs) injected into the ventricle of 30-h pf zebrafish embryos caused a marked defasciculation of distinct axon bundles in the posterior commissure, in hindbrain commissures, and in longitudinal tracts of the hindbrain, where they also caused increased crossings between fascicles. The regulated expression of E587 antigen by all developing axons and the effects caused by E587 Fabs show that E587 antigen contributes to the formation of tight and orderly fascicles in the developing CNS.

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570 Biowissenschaften, Biologie
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ISO 690WEILAND, Ulrich M., Heiko OTT, Martin BASTMEYER, Herbert SCHADEN, Suzanne GIORDANO, Claudia STÜRMER, 1997. Expression of an L1-Related Cell Adhesion Molecule on Developing CNS Fiber Tracts in Zebrafish and Its Functional Contribution to Axon Fasciculation. In: Molecular and Cellular Neuroscience. 1997, 9(1), pp. 77-89. ISSN 1044-7431. Available under: doi: 10.1006/mcne.1997.0603
BibTex
@article{Weiland1997Expre-7330,
  year={1997},
  doi={10.1006/mcne.1997.0603},
  title={Expression of an L1-Related Cell Adhesion Molecule on Developing CNS Fiber Tracts in Zebrafish and Its Functional Contribution to Axon Fasciculation},
  number={1},
  volume={9},
  issn={1044-7431},
  journal={Molecular and Cellular Neuroscience},
  pages={77--89},
  author={Weiland, Ulrich M. and Ott, Heiko and Bastmeyer, Martin and Schaden, Herbert and Giordano, Suzanne and Stürmer, Claudia}
}
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