Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down Syndrome

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2022
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Morsiani, Cristina
Bacalini, Maria Giulia
Collura, Salvatore
Breusing, Nicolle
Grune, Tilman
Franceschi, Claudio
De Eguileor, Magda
Capri, Miriam
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Persons with Down Syndrome (DS) undergo a premature ageing with early onset of age-related diseases. The main endpoint of this study was the identification of blood circulating microRNAs (c-miRs) signatures characterizing DS ageing process. A discovery phase based on array was performed in plasma samples obtained from 3 young (31±2 years-old) and 3 elderly DS persons (66±2 years-old). Then, a validation phase was carried out for relevant miRs by RT-qPCR in an enlarged cohort of 43 DS individuals (from 19 up to 68 years-old). A group of 30 non-trisomic subjects, as representative of physiological ageing, was compared. In particular miR-628-5p, miR-152-3p, miR-28-5p, and let-7d-5p showed a lower level in younger DS persons (age ≤ 50 years) respect to the age-matched controls. Among those, miR-28-5p and let-7d-5p were found significantly decreased in physiological ageing (control group with age threshold of 50 years), thus they emerged as possible biomarkers of premature ageing in DS. Moreover, measuring blood levels of beta amyloid peptides, Aβ-42 was assessed at the lowest levels in physiological ageing and correlated with miR-28-5p and let-7d-5p in DS, while Aβ-40 correlated with miR-628-5p in the same cohort. New perspectives in terms of biomarkers are discussed.

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570 Biowissenschaften, Biologie
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MicroRNAs,Amyloid beta, Down syndrome, Premature ageing
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ISO 690MORSIANI, Cristina, Maria Giulia BACALINI, Salvatore COLLURA, Maria MORENO-VILLANUEVA, Nicolle BREUSING, Alexander BÜRKLE, Tilman GRUNE, Claudio FRANCESCHI, Magda DE EGUILEOR, Miriam CAPRI, 2022. Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down Syndrome. In: Mechanisms of ageing and development. Elsevier. 2022, 206, 111691. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2022.111691
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@article{Morsiani2022-06-30Blood-57995,
  year={2022},
  doi={10.1016/j.mad.2022.111691},
  title={Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down Syndrome},
  volume={206},
  issn={0047-6374},
  journal={Mechanisms of ageing and development},
  author={Morsiani, Cristina and Bacalini, Maria Giulia and Collura, Salvatore and Moreno-Villanueva, Maria and Breusing, Nicolle and Bürkle, Alexander and Grune, Tilman and Franceschi, Claudio and De Eguileor, Magda and Capri, Miriam},
  note={Article Number: 111691}
}
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