Close the ring to break the cycle : tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity

Szamosvari, David; Sylvester, Kayla; Schmid, Philipp; Lu, Kuan-Yi; Derbyshire, Emily R.; Böttcher, Thomas

Close the ring to break the cycle : tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2019

Autor:innen

Szamosvari, David

Sylvester, Kayla

Schmid, Philipp

Lu, Kuan-Yi

Derbyshire, Emily R.

Böttcher, Thomas

DOI (zitierfähiger Link)

https://doi.org/10.1039/C9CC01689A

Sammlungen

Chemie
Zukunftskolleg

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Chemical Communications : ChemComm. 2019, 55(49), pp. 7009-7012. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/C9CC01689A

Zusammenfassung

Expanding the chemical space of quinolones led to a tandem quinolone-alkyne-cyclisation reaction allowing chemoselective control of the synthesis of tricyclic pyrrolo[1,2-a]quinolin-5-ones. Importantly, we discovered anti-protozoal activity against Plasmodium and Toxoplasma with specific potency of one of the compounds against the liver stage of the malaria parasite in the nanomolar range.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

SZAMOSVARI, David, Kayla SYLVESTER, Philipp SCHMID, Kuan-Yi LU, Emily R. DERBYSHIRE, Thomas BÖTTCHER, 2019. Close the ring to break the cycle : tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity. In: Chemical Communications : ChemComm. 2019, 55(49), pp. 7009-7012. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/C9CC01689A

BibTex

@article{Szamosvari2019-06-13Close-45977,
  year={2019},
  doi={10.1039/C9CC01689A},
  title={Close the ring to break the cycle : tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity},
  number={49},
  volume={55},
  issn={0009-241X},
  journal={Chemical Communications : ChemComm},
  pages={7009--7012},
  author={Szamosvari, David and Sylvester, Kayla and Schmid, Philipp and Lu, Kuan-Yi and Derbyshire, Emily R. and Böttcher, Thomas}
}

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Universitätsbibliographie

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